Genome-scale metabolic models of Saccharomyces cerevisiae
Kapitel i bok, 2011

Systematic analysis of Saccharomyces cerevisiae metabolic functions and pathways has been the subject of extensive studies and established in many aspects. With the reconstruction of the yeast genome-scale metabolic (GSM) network and in silico simulation of the GSM model, the nature of the underlying cellular processes can be tested and validated with the increasing metabolic knowledge. GSM models are also being exploited in fundamental research studies and industrial applications. In this chapter, the principle concepts for construction, simulation and validation of GSM models, progressive applications of the yeast GSM models, and future perspectives are described. This will support and encourage researchers who are interested in systemic analysis of yeast metabolism and systems biology.

genome-scale metabolic model (GSM)

yeast

metabolism

Saccharomyces cerevisia

metabolic network reconstruction

systems biology

Författare

Intawat Nookaew

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Roberto Olivares Hernandez

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

S. Bhumiratana

Thailand National Science and Technology Development Agency

Jens B Nielsen

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Methods in molecular biology (Clifton, N.J.)

1064-3745 (ISSN)

445-463

Ämneskategorier

Biokemi och molekylärbiologi

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1007/978-1-61779-173-4_25

ISBN

978-161779172-7