Systems biology of lipid metabolism: From yeast to human
Journal article, 2009
Lipid metabolism is highly relevant as it plays a central role in a number of human diseases. Due to the highly interactive structure of lipid metabolism and its regulation, it is necessary to apply a holistic approach, and systems biology is therefore well suited for integrated analysis of lipid metabolism. In this paper it is demonstrated that the yeast Saccharomyces cerevisiae serves as an excellent model organism for studying the regulation of lipid metabolism in eukaryotes as most of the regulatory structures in this part of the metabolism are conserved between yeast and mammals. Hereby yeast systems biology can assist to improve our understanding of how lipid metabolism is regulated. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Metabolic model
glucose repression
reconstruction
phospholipid
genes
Lipid metabolism
proteins
models
fatty-acid
transcription factors
networks reveals
saccharomyces-cerevisiae
biosynthesis
Yeast
Systems biology
Author
Jens B Nielsen
Chalmers, Chemical and Biological Engineering, Life Sciences
FEBS Letters
0014-5793 (ISSN) 18733468 (eISSN)
Vol. 583 24 3905-3913Areas of Advance
Life Science Engineering (2010-2018)
Subject Categories
Other Industrial Biotechnology
DOI
10.1016/j.febslet.2009.10.054