Systems biology of lipid metabolism: From yeast to human
Artikel i vetenskaplig tidskrift, 2009

Lipid metabolism is highly relevant as it plays a central role in a number of human diseases. Due to the highly interactive structure of lipid metabolism and its regulation, it is necessary to apply a holistic approach, and systems biology is therefore well suited for integrated analysis of lipid metabolism. In this paper it is demonstrated that the yeast Saccharomyces cerevisiae serves as an excellent model organism for studying the regulation of lipid metabolism in eukaryotes as most of the regulatory structures in this part of the metabolism are conserved between yeast and mammals. Hereby yeast systems biology can assist to improve our understanding of how lipid metabolism is regulated. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Metabolic model

glucose repression

reconstruction

phospholipid

genes

Lipid metabolism

proteins

models

fatty-acid

transcription factors

networks reveals

saccharomyces-cerevisiae

biosynthesis

Yeast

Systems biology

Författare

Jens B Nielsen

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

FEBS Letters

0014-5793 (ISSN)

Vol. 583 3905-3913

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Annan industriell bioteknik

DOI

10.1016/j.febslet.2009.10.054