Carbohydrate active enzymes are affected by diet transition from milk to solid food in infant gut microbiota
Journal article, 2019

Infants experience a dramatic change in their food in the first year after birth when they shift from breast milk to solid food. This results in a large change in presence of indigestible polysaccharides, a primary energy resource of gut microbes. How the gut microbiota adapts to this dietary shift has not been well examined. Here, by using metagenomics data, we studied carbohydrate-active enzymes (CAZymes) of gut microbiota, which are essential enzymes catalyzing the breakdown of polysaccharides, during this dietary shift. We developed a new approach to categorize CAZyme families by food intake and found CAZyme families associated with milk or solid food. We also found CAZymes with most abundance in 12 months infants that are not associated with solid food or milk but may be related to modulating carbohydrates in the mucus. Additionally, the abundance of gut CAZymes were found to be affected by many other factors, including delivery modes and life style in adults. Taken together, our findings provide novel insights into the dynamic change of gut CAZymes in early human life and provide potential markers for food interference or gut microbiota restoration.

carbohydrate-active enzymes

infant

metagenomics

gut microbiota

CAZymes

Author

Ling Qun Ye

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Promi Das

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Peishun Li

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Boyang Ji

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

BioInnovation Institute

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Technical University of Denmark (DTU)

FEMS microbiology ecology

15746941 (eISSN)

Vol. 95 11 Fiz159

Subject Categories

Food Science

Ecology

Nutrition and Dietetics

DOI

10.1093/femsec/fiz159

PubMed

31589310

More information

Latest update

12/6/2019