Aspergilli: Systems biology and industrial applications
Review article, 2012
Aspergilli are widely used as cell factories for the production of food ingredients, enzymes and antibiotics. Traditionally, improvement of these cell factories has been done using classical methods, that is, random mutagenesis and screening; however, advances in methods for performing directed genetic modifications has enabled the use of metabolic engineering strategies. Genome sequencing of Aspergilli was originally trailing behind developments in the field of bacteria and yeasts, but with the recent availability of genome sequences for several industrially relevant Aspergilli, it has become possible to implement systems biology tools to advance metabolic engineering. These tools include genome-wide transcription analysis and genome-scale metabolic models. Herein, we review achievements in the field and highlight the impact of Aspergillus systems biology on industrial biotechnology.
genome
nidulans
steady-state
Metabolic engineering
proteomics
citric-acid accumulation
fluxes
niger
Systems biology
modeling approach
metabolic control analysis
Aspergillus
carbohydrate-metabolism
Industrial biotechnology
Author
Christoph Knuf
Chalmers, Chemical and Biological Engineering, Life Sciences
Jens B Nielsen
Chalmers, Chemical and Biological Engineering, Life Sciences
Biotechnology journal
1860-6768 (ISSN) 1860-7314 (eISSN)
Vol. 7 9 1147-1155Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO)
European Commission (EC) (EC/FP7/247013), 2010-01-01 -- 2014-12-31.
Subject Categories
Biological Sciences
Areas of Advance
Energy
Life Science Engineering (2010-2018)
DOI
10.1002/biot.201200169