Aspergilli: Systems biology and industrial applications
Reviewartikel, 2012
Aspergilli are widely used as cell factories for the production of food ingredients, enzymes and antibiotics. Traditionally, improvement of these cell factories has been done using classical methods, that is, random mutagenesis and screening; however, advances in methods for performing directed genetic modifications has enabled the use of metabolic engineering strategies. Genome sequencing of Aspergilli was originally trailing behind developments in the field of bacteria and yeasts, but with the recent availability of genome sequences for several industrially relevant Aspergilli, it has become possible to implement systems biology tools to advance metabolic engineering. These tools include genome-wide transcription analysis and genome-scale metabolic models. Herein, we review achievements in the field and highlight the impact of Aspergillus systems biology on industrial biotechnology.
genome
nidulans
steady-state
Metabolic engineering
proteomics
citric-acid accumulation
fluxes
niger
Systems biology
modeling approach
metabolic control analysis
Aspergillus
carbohydrate-metabolism
Industrial biotechnology
Författare
Christoph Knuf
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Jens B Nielsen
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Biotechnology journal
1860-6768 (ISSN) 1860-7314 (eISSN)
Vol. 7 9 1147-1155Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO)
Europeiska kommissionen (EU) (EC/FP7/247013), 2010-01-01 -- 2014-12-31.
Ämneskategorier
Biologiska vetenskaper
Styrkeområden
Energi
Livsvetenskaper och teknik (2010-2018)
DOI
10.1002/biot.201200169