Expanding the product portfolio of fungal type I fatty acid synthases
Journal article, 2017

Fungal type I fatty acid synthases (FASs) are mega-enzymes with two separated, identical compartments, in which the acyl carrier protein (ACP) domains shuttle substrates to catalytically active sites embedded in the chamber wall. We devised synthetic FASs by integrating heterologous enzymes into the reaction chambers and demonstrated their capability to convert acyl-ACP or acyl-CoA from canonical fatty acid biosynthesis to short/ medium-chain fatty acids and methyl ketones.

rhodosporidium-toruloides

expression

saccharomyces-cerevisiae

yeast

genes

fas

Author

Zhu Zhiwei

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Yongjin Zhou

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Anastasia Krivoruchko

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

M. Grininger

Goethe University Frankfurt

Z. B. K. Zhao

Chinese Academy of Sciences

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Nature Chemical Biology

1552-4450 (ISSN) 1552-4469 (eISSN)

Vol. 13 4 360-362

Driving Forces

Sustainable development

Subject Categories

Biochemistry and Molecular Biology

Biocatalysis and Enzyme Technology

Organic Chemistry

Infrastructure

Chalmers Infrastructure for Mass spectrometry

Roots

Basic sciences

Areas of Advance

Life Science Engineering (2010-2018)

DOI

10.1038/nchembio.2301

PubMed

28218911

More information

Latest update

10/2/2018