Fifteen years of large scale metabolic modeling of yeast: Developments and impacts
Review article, 2012

Since the first large-scale reconstruction of the Saccharomyces cerevisiae metabolic network 15 years ago the development of yeast metabolic models has progressed rapidly, resulting in no less than nine different yeast genome-scale metabolic models. Here we review the historical development of large-scale mathematical modeling of yeast metabolism and the growing scope and impact of applications of these models in four different areas: as guide for metabolic engineering and strain improvement, as a tool for biological interpretation and discovery, applications of novel computational framework and for evolutionary studies.

Metabolic engineering

Evolution

network topology

saccharomyces-cerevisiae

ethanol-production

subcellular-localization

analysis

Systems biology

integrated analysis

Computational algorithms

systems biology

in-silico

pathway

Genome-scale metabolic model

escherichia-coli

flux balance analysis

Author

Tobias Österlund

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Intawat Nookaew

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Biotechnology Advances

0734-9750 (ISSN)

Vol. 30 5 979-988

Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO)

European Commission (EC) (EC/FP7/247013), 2010-01-01 -- 2014-12-31.

Subject Categories

Microbiology

Areas of Advance

Life Science Engineering (2010-2018)

DOI

10.1016/j.biotechadv.2011.07.021

More information

Latest update

7/20/2021