Fifteen years of large scale metabolic modeling of yeast: Developments and impacts
Review article, 2012
Since the first large-scale reconstruction of the Saccharomyces cerevisiae metabolic network 15 years ago the development of yeast metabolic models has progressed rapidly, resulting in no less than nine different yeast genome-scale metabolic models. Here we review the historical development of large-scale mathematical modeling of yeast metabolism and the growing scope and impact of applications of these models in four different areas: as guide for metabolic engineering and strain improvement, as a tool for biological interpretation and discovery, applications of novel computational framework and for evolutionary studies.
Metabolic engineering
Evolution
network topology
saccharomyces-cerevisiae
ethanol-production
subcellular-localization
analysis
Systems biology
integrated analysis
Computational algorithms
systems biology
in-silico
pathway
Genome-scale metabolic model
escherichia-coli
flux balance analysis
Author
Tobias Österlund
Chalmers, Chemical and Biological Engineering, Life Sciences
Intawat Nookaew
Chalmers, Chemical and Biological Engineering, Life Sciences
Jens B Nielsen
Chalmers, Chemical and Biological Engineering, Life Sciences
Biotechnology Advances
0734-9750 (ISSN)
Vol. 30 5 979-988Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO)
European Commission (EC) (EC/FP7/247013), 2010-01-01 -- 2014-12-31.
Subject Categories
Microbiology
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.1016/j.biotechadv.2011.07.021