A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity
Journal article, 2022
Non-alcoholic fatty liver disease (NAFLD) is now the most frequent global chronic liver disease. Individuals with NAFLD exhibited an increased risk of all-cause mortality driven by extrahepatic cancers and liver and cardiovascular disease. Once the disease is established, women have a higher risk of disease progression and worse outcome. It is therefore critical to deepen the current knowledge on the pathophysiology of NAFLD in women. Here, we used a systems biology approach to investigate the contribution of different organs to this disease. We analyzed transcriptomics profiles of liver and adipose tissues, fecal metagenomes, and plasma metabolomes of 55 women with and without NAFLD. We observed differences in metabolites, expression of human genes, and gut microbial features between the groups and revealed that there is substantial crosstalk between these different omics sets. Multi-omics analysis of individuals with NAFLD may provide novel strategies to study the pathophysiology of NAFLD in humans.
Human metabolism
Physiology
Systems biology
Biological sciences
Author
A. S. Meijnikman
University of Amsterdam
Spaarne Hospital
Dimitra Lappa
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
H. Herrema
University of Amsterdam
O. Aydin
Spaarne Hospital
University of Amsterdam
Kimberly A. Krautkramer
Wallenberg Lab.
Valentina Tremaroli
Wallenberg Lab.
L. E. Olofsson
Wallenberg Lab.
Annika Lundqvist
Wallenberg Lab.
S. C. Bruin
Spaarne Hospital
Y. I.Z. Acherman
Spaarne Hospital
J. Verheij
University of Amsterdam
S. Hjorth
University of Copenhagen
V. E.A. Gerdes
Spaarne Hospital
University of Amsterdam
Thue W. Schwartz
University of Copenhagen
A. K. Groen
University of Amsterdam
Fredrik Bäckhed
University of Copenhagen
Wallenberg Lab.
Sahlgrenska University Hospital
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
M. Nieuwdorp
University of Amsterdam
iScience
25890042 (eISSN)
Vol. 25 8 104828Subject Categories
Other Clinical Medicine
Gastroenterology and Hepatology
Obstetrics, Gynecology and Reproductive Medicine
DOI
10.1016/j.isci.2022.104828
PubMed
35992074