A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity
Artikel i vetenskaplig tidskrift, 2022
Non-alcoholic fatty liver disease (NAFLD) is now the most frequent global chronic liver disease. Individuals with NAFLD exhibited an increased risk of all-cause mortality driven by extrahepatic cancers and liver and cardiovascular disease. Once the disease is established, women have a higher risk of disease progression and worse outcome. It is therefore critical to deepen the current knowledge on the pathophysiology of NAFLD in women. Here, we used a systems biology approach to investigate the contribution of different organs to this disease. We analyzed transcriptomics profiles of liver and adipose tissues, fecal metagenomes, and plasma metabolomes of 55 women with and without NAFLD. We observed differences in metabolites, expression of human genes, and gut microbial features between the groups and revealed that there is substantial crosstalk between these different omics sets. Multi-omics analysis of individuals with NAFLD may provide novel strategies to study the pathophysiology of NAFLD in humans.
Human metabolism
Physiology
Systems biology
Biological sciences
Författare
A. S. Meijnikman
Universiteit Van Amsterdam
Spaarne Gasthuis
Dimitra Lappa
Chalmers, Biologi och bioteknik, Systembiologi
H. Herrema
Universiteit Van Amsterdam
O. Aydin
Spaarne Gasthuis
Universiteit Van Amsterdam
Kimberly A. Krautkramer
Wallenberg Lab.
Valentina Tremaroli
Wallenberg Lab.
L. E. Olofsson
Wallenberg Lab.
Annika Lundqvist
Wallenberg Lab.
S. C. Bruin
Spaarne Gasthuis
Y. I.Z. Acherman
Spaarne Gasthuis
J. Verheij
Universiteit Van Amsterdam
S. Hjorth
Köpenhamns universitet
V. E.A. Gerdes
Spaarne Gasthuis
Universiteit Van Amsterdam
Thue W. Schwartz
Köpenhamns universitet
A. K. Groen
Universiteit Van Amsterdam
Fredrik Bäckhed
Köpenhamns universitet
Wallenberg Lab.
Sahlgrenska universitetssjukhuset
Jens B Nielsen
Chalmers, Biologi och bioteknik, Systembiologi
M. Nieuwdorp
Universiteit Van Amsterdam
iScience
25890042 (eISSN)
Vol. 25 8 104828Ämneskategorier (SSIF 2011)
Annan klinisk medicin
Gastroenterologi
Reproduktionsmedicin och gynekologi
DOI
10.1016/j.isci.2022.104828
PubMed
35992074