Integrated Analysis of the Global Transcriptional Response to alpha-Amylase Over-Production by Aspergillus oryzae
Journal article, 2011

The filamentous fungus Aspergillus oryzae is an important microbial cell factory for industrial production of many enzymes, such as alpha-amylase. In order to optimize the industrial enzyme production process, there is a need to understand fundamental processes underlying enzyme production, here under how enzyme production links to metabolism through global regulation. Through a genome-scale metabolic network for integrated analysis of transcriptome data and flux calculation, we identified key players (genes, enzymes, proteins, and metabolites) involved in the processes of enzyme synthesis and secretion, nucleotide metabolism, and amino acid metabolism that can be the potential targets for improving industrial enzyme production. Biotechnol. Bioeng. 2011;108: 1130-1139.

systems biology

amino-acid biosynthesis


probe level

data integration

general control

enzyme production

Aspergillus oryzae




Wanwipa Vongsangnak

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

K. Hansen

Novozymes A/S

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Biotechnology and Bioengineering

0006-3592 (ISSN) 1097-0290 (eISSN)

Vol. 108 5 1130-1139

Driving Forces

Sustainable development

Subject Categories

Industrial Biotechnology

Areas of Advance


Life Science Engineering (2010-2018)



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