Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures
Journal article, 2022

Triple negative breast cancer (TNBC) metastases are assumed to exhibit similar functions in different organs as in the original primary tumor. However, studies of metastasis are often limited to a comparison of metastatic tumors with primary tumors of their origin, and little is known about the adaptation to the local environment of the metastatic sites. We therefore used transcriptomic data and metabolic network analyses to investigate whether metastatic tumors adapt their metabolism to the metastatic site and found that metastatic tumors adopt a metabolic signature with some similarity to primary tumors of their destinations. The extent of adaptation, however, varies across different organs, and metastatic tumors retain metabolic signatures associated with TNBC. Our findings suggest that a combination of anti-metastatic approaches and metabolic inhibitors selected specifically for different metastatic sites, rather than solely targeting TNBC primary tumors, may constitute a more effective treatment approach.

gene expression

systems biology

metastasis

triple negative breast cancer

genome-scale metabolic models

Author

Fariba Roshanzamir

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

University of Tehran

Jonathan Robinson

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Daniel John Cook

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Mohammad Hossein Karimi-Jafari

University of Tehran

Jens B Nielsen

BioInnovation Institute

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Proceedings of the National Academy of Sciences of the United States of America

0027-8424 (ISSN) 1091-6490 (eISSN)

Vol. 119 35 e2205456119

Subject Categories

Cancer and Oncology

DOI

10.1073/pnas.2205456119

PubMed

35994654

More information

Latest update

9/2/2022 1