Perspective: Metabotyping—A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease
Review article, 2020
Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease. Recent evidence suggests that individuals could benefit from diets adapted to their genotype and phenotype: that is, personalized nutrition. A novel strategy is to tailor diets for groups of individuals according to their metabolic phenotypes (metabotypes). Randomized controlled trials evaluating metabotype-specific responses and nonresponses are urgently needed to bridge the current gap of knowledge with regard to the efficacy of personalized strategies in nutrition. In this Perspective, we discuss the concept of metabotyping, review the current literature on metabotyping in the context of cardiometabolic disease prevention, and suggest potential strategies for metabotype-based nutritional advice for future work. We also discuss potential determinants of metabotypes, including gut microbiota, and highlight the use of metabolomics to define effective markers for cardiometabolic disease-related metabotypes. Moreover, we hypothesize that people at high risk for cardiometabolic diseases have distinct metabotypes and that individuals grouped into specific metabotypes may respond differently to the same diet, which is being tested in a project of the Joint Programming Initiative: A Healthy Diet for a Healthy Life.
precision nutrition
targeted nutrition
cardiometabolic diseases
gut microbiota
metabotyping
personalized nutrition
metabolomics
Author
Marie Palmnäs
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Carl Brunius
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Lin Shi
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Shaanxi Normal University
Agnetha Rostgaard-Hansen
Danish Cancer Research Society Center
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Núria Estanyol Torres
University of Barcelona
Institute of Health Carlos III
Raúl González-Domínguez
University of Barcelona
Institute of Health Carlos III
Raúl Zamora-Ros
University of Barcelona
Bellvitge Biomedical Research Institute IDIBELL
Ling Qun Ye
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Jytte Halkjær
Danish Cancer Research Society Center
Anne Tjønneland
Danish Cancer Research Society Center
Gabriele Riccardi
University of Naples Federico II
Rosalba Giacco
University of Naples Federico II
National Research Council of Italy (CNR)
Giuseppina Costabile
University of Naples Federico II
Claudia Vetrani
University of Naples Federico II
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Cristina Andres-Lacueva
University of Barcelona
Institute of Health Carlos III
Rikard Landberg
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Umeå University
Advances in nutrition (Bethesda, Md.)
21618313 (ISSN) 21565376 (eISSN)
Vol. 11 3 524-532DiGuMet Project: Diet x gut microbiome-based metabotypes to determine cardio-metabolic risk and tailor intervention strategies for improved health
Formas (2017-02003), 2018-01-01 -- 2021-12-31.
Subject Categories
Biological Sciences
Health Sciences
Nutrition and Dietetics
DOI
10.1093/advances/nmz121
PubMed
31782487