Multiscale models quantifying yeast physiology: towards a whole-cell model
Review article, 2021

The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important eukaryal model organism for studying cellular physiology related to human health and disease. Yeast was also the first eukaryal organism for which a genome-scale metabolic model (GEM) was developed. In recent years there has been interest in expanding the modeling framework for yeast by incorporating enzymatic parameters and other heterogeneous cellular networks to obtain a more comprehensive description of cellular physiology. We review the latest developments in multiscale models of yeast, and illustrate how a new generation of multiscale models could significantly enhance the predictive performance and expand the applications of classical GEMs in cell factory design and basic studies of yeast physiology.

whole-cell model

S. cerevisiae

multiscale model

yeast species

Author

Hongzhong Lu

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Eduard Kerkhoven

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

BioInnovation Institute

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Trends in Biotechnology

0167-7799 (ISSN)

Vol. In Press

Subject Categories

Bioinformatics (Computational Biology)

Bioinformatics and Systems Biology

Probability Theory and Statistics

DOI

10.1016/j.tibtech.2021.06.010

More information

Latest update

8/6/2021 1