Eduard Kerkhoven

Forskare at Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Dr. Eduard Kerkhoven is a project leader in the department of Biology and Biological Engineering. His interest is in the use of computational models of metabolism, and he is involved in both the generation of these models and the experimental testing of hypotheses derived from the modeling. These models can be genome-scale reconstructions, or small-scale dynamic models. In particular, Eduard’s research is focused on the use of microbial cell factories, such as the yeast Yarrowia lipolytica, that can be used to generate biofuels.

Source: chalmers.se

Projects

2016–2018

From electricity towards biodiesel production in yeast

Eduard Kerkhoven Systems and Synthetic Biology
ÅForsk (Ångpanneföreningens Foundation for Research and Development)

2015–2018

Systematic Rebuilding of Actinomycetes for Natural Product Formation (ERASysAPP - SYSTERACT)

Eduard Kerkhoven Systems and Synthetic Biology
Region Västra Götaland

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Publications

2017

A molecular genetic toolbox for Yarrowia lipolytica

Erin L. Bredeweg, Kyle R. Pomraning, Ziyu Dai et al
Biotechnology for Biofuels. Vol. 10 (1)
Journal article
2017

Leucine Biosynthesis Is Involved in Regulating High Lipid Accumulation in Yarrowia lipolytica

Eduard Kerkhoven, Y. M. Kim, S. W. Wei et al
mBio. Vol. 8 (3), p. Article no. e00857-17
Journal article
2017

Improving the phenotype predictions of a yeast genome-scale metabolic model by incorporating enzymatic constraints

Benjamin José Sanchez Barja, C. Zhang, Avlant Nilsson et al
Molecular Systems Biology. Vol. 13 (8), p. Article no 935 -
Journal article
2016

Genome-scale metabolic model of Pichia pastoris with native and humanized glycosylation of recombinant proteins

Z. A. Irani, Eduard Kerkhoven, S. A. Shojaosadati et al
Biotechnology and Bioengineering. Vol. 113 (5), p. 961-969
Journal article
2015

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose

D. J. Creek, M. Mazet, F. Achcar et al
PLoS Pathogens. Vol. 11 (3), p. 1-25
Journal article
2015

Applications of computational modeling in metabolic engineering of yeast

Eduard Kerkhoven, Petri-Jaan Lahtvee, Jens B Nielsen
FEMS Yeast Research. Vol. 15 (1)
Journal article
2015

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

S. Shameer, F. J. Logan-Klumpler, F. Vinson et al
Nucleic Acids Research. Vol. 43 (D1), p. D637-D644
Journal article
2015

Crystal Structure of an Arginase-like Protein from Trypanosoma brucei That Evolved without a Binuclear Manganese Cluster

Y. Hai, Eduard Kerkhoven, M. P. Barrett et al
Biochemistry. Vol. 54 (2), p. 458-471
Journal article
2014

The Silicon Trypanosome: A Test Case of Iterative Model Extension in Systems Biology

F. Achcar, A. Fadda, J. R. Haanstra et al
Advances in Microbial Physiology. Vol. 64, p. 115-143
Chapter in monograph, book - peer reviewed
2014

Trypanosoma brucei: meet the system

F. Achcar, Eduard Kerkhoven, M. P. Barrett
Current Opinion in Microbiology. Vol. 20, p. 162-169
Journal article
2014

Genome Scale Metabolic Modeling of the Riboflavin Overproducer Ashbya gossypii

R. Ledesma-Amaro, Eduard Kerkhoven, J. L. Revuelta et al
Biotechnology and Bioengineering. Vol. 111 (6), p. 1191-1199
Journal article
2013

Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei

Eduard Kerkhoven, F. Achcar, V. P. Alibu et al
PLoS Computational Biology. Vol. 9 (12), p. Art. no. e1003371-
Journal article