The Silicon Trypanosome: A Test Case of Iterative Model Extension in Systems Biology
Book chapter, 2014

The African trypanosome, Ttypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology.


F. Achcar

University of Glasgow

A. Fadda

Heidelberg University

J. R. Haanstra

University of Groningen

Free University of Amsterdam

Eduard Kerkhoven

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

D. H. Kim

Wellcome Trust Centre for Molecular Parasitology

A. E. Leroux

Heidelberg University

T. Papamarkou

University College London (UCL)

F. Rojas

University of Edinburgh

B.M. Bakker

University of Groningen

M. P. Barrett

Wellcome Trust Centre for Molecular Parasitology

C. Clayton

Heidelberg University

M. Girolami

University College London (UCL)

R. L. Krauth-Siegel

Heidelberg University

K. R. Matthews

University of Edinburgh

R. Breitling

University of Manchester

Advances in Microbial Physiology

0065-2911 (ISSN)

Vol. 64 115-143

Subject Categories

Chemical Sciences





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