The Silicon Trypanosome: A Test Case of Iterative Model Extension in Systems Biology
Kapitel i bok, 2014

The African trypanosome, Ttypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology.


F. Achcar

University of Glasgow

A. Fadda

Universität Heidelberg

J. R. Haanstra

Rijksuniversiteit Groningen

VU University Amsterdam

Eduard Kerkhoven

Kemi- och bioteknik, Livsvetenskaper, Systembiologi

D. H. Kim

Wellcome Trust Centre for Molecular Parasitology

A. E. Leroux

Universität Heidelberg

T. Papamarkou

University College London (UCL)

F. Rojas

University of Edinburgh

B.M. Bakker

Rijksuniversiteit Groningen

M. P. Barrett

Wellcome Trust Centre for Molecular Parasitology

C. Clayton

Universität Heidelberg

M. Girolami

University College London (UCL)

R. L. Krauth-Siegel

Universität Heidelberg

K. R. Matthews

University of Edinburgh

R. Breitling

University of Manchester

Advances in Microbial Physiology

0065-2911 (ISSN)

Vol. 64 115-143