Trypanosoma brucei: meet the system
Review article, 2014
African trypanosomes cause devastating diseases in humans and domestic animals. The parasites evolved early in the eukaryotic lineage and have numerous biochemical peculiarities that distinguish them from other systems. These include unconventional mechanisms for expressing nuclear and mitochondrial genes as well as unusual subcellular localizations for a variety of enzymes. Systems biology has arisen partly to allow contextualization of the massive datasets that describe individual chemical parts of biological systems. Here we describe recent efforts to collect and analyse data pertaining to all aspects of the trypanosome's biochemical physiology that go some way to describing the parasite as an integrated system.
RESISTANCE
BLOOD-STREAM-FORM
COMPARATIVE PROTEOMICS
MITOCHONDRIAL METABOLISM
PARASITE
IMMUNE EVASION
LIFE-CYCLE STAGES
GENE-EXPRESSION
DIFFERENTIATION
AFRICAN TRYPANOSOMES
ANTIGENIC VARIATION
Author
F. Achcar
Wellcome Trust Centre for Molecular Parasitology
Eduard Kerkhoven
Chalmers, Chemical and Biological Engineering, Life Sciences
M. P. Barrett
Wellcome Trust Centre for Molecular Parasitology
Current Opinion in Microbiology
1369-5274 (ISSN) 18790364 (eISSN)
Vol. 20 162-169Subject Categories
Microbiology
DOI
10.1016/j.mib.2014.06.007