Systematic Rebuilding of Actinomycetes for Natural Product Formation (ERASysAPP - SYSTERACT)

Despite an increasing medical need, the number of new antibiotics approved for human use has been declining over many years. Recently, new molecular genetics and biochemical tools, and in particular Next Generation Sequencing, combined with newly developed bioinformatics approaches, have provided insight into the enormous unexploited genetic pool of environmental microbial biodiversities for the synthesis of potential new bioactive compounds. The main objective of the SYSTERACT project is through an integrated and interdisciplinary approach to develop the model actinomycete Streptomyces coelicolor into a 'Superhost' for the efficient heterologous production of bioactive compounds, enabling a faster discovery of new antibiotics from environmental microbial resources (microbial strains and metagenomes). Central to this approach will be an iterative Systems Biology process, combining microbiology, genetics, biochemistry, and fermentation technology with modelling.

Participants

Eduard Kerkhoven (contact)

Forskare vid Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Collaborations

Leiden University

Leiden, Netherlands

SINTEF

Trondheim, Norway

Universitaet Rostock

Rostock, Germany

University of Tübingen

Tübingen, Germany

Funding

Region Västra Götaland

Funding years 2015–2018

Related Areas of Advance and Infrastructure

Sustainable development

Driving Forces

Life Science Engineering

Areas of Advance

More information

Latest update

2015-11-02