Systematic Rebuilding of Actinomycetes for Natural Product Formation (ERASysAPP - SYSTERACT)
Research Project, 2015
– 2018
Despite an increasing medical need, the number of new antibiotics approved for human use has been declining over many years. Recently, new molecular genetics and biochemical tools, and in particular Next Generation Sequencing, combined with newly developed bioinformatics approaches, have provided insight into the enormous unexploited genetic pool of environmental microbial biodiversities for the synthesis of potential new bioactive compounds. The main objective of the SYSTERACT project is through an integrated and interdisciplinary approach to develop the model actinomycete Streptomyces coelicolor into a 'Superhost' for the efficient heterologous production of bioactive compounds, enabling a faster discovery of new antibiotics from environmental microbial resources (microbial strains and metagenomes). Central to this approach will be an iterative Systems Biology process, combining microbiology, genetics, biochemistry, and fermentation technology with modelling.
Participants
Eduard Kerkhoven (contact)
Chalmers, Life Sciences, Systems and Synthetic Biology
Collaborations
Leiden University
Leiden, Netherlands
SINTEF
Trondheim, Norway
University of Rostock
Rostock, Germany
University of Tübingen
Tübingen, Germany
Funding
Region Västra Götaland
Project ID: RUN 612-0436-15
Funding Chalmers participation during 2015–2018
Related Areas of Advance and Infrastructure
Sustainable development
Driving Forces
Life Science Engineering (2010-2018)
Areas of Advance