Kinetic Models of Metabolism
Book chapter, 2021

This chapter introduces the kinetic models of metabolism followed by examples on the construction of kinetic models as well as applications. With the Michaelis-Menten formulation, the influence of enzyme properties, enzyme abundance, and metabolite concentration on the dynamic behavior of a reaction can be explained mechanistically. Kinetic models mechanistically represent the processes that take place within a cell, and these models are made up of a series of ordinary differential equations. A kinetic model requires the definition of rate equations and their respective parameters for each of the reactions, which are currently unknown for many of the reactions contained in genome-scale models. Reaction kinetics can be described with mathematical expressions where the reaction rates are functions of kinetic parameters and the concentration of metabolites. Approximative rate expression is also adopted in the kinetic model reconstruction. Estimation of parameters in rate expressions is essential for having good predictive performance of a kinetic model.

mathematical expressions

dynamic behaviour

approximative rate expression

reaction rate

metabolism

rate expressions

Michaelis-Menten formulation

kinetic model

Author

Hongzhong Lu

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Yu Chen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

BioInnovation Institute

Eduard Kerkhoven

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Metabolic Engineering: Concepts and Applications: Volume 13a and 13b

Vol. 13 153-170
9783527823468 (ISBN)

Subject Categories

Pharmaceutical Sciences

Applied Mechanics

Probability Theory and Statistics

DOI

10.1002/9783527823468.ch5

More information

Latest update

7/12/2024