Multiscale models quantifying yeast physiology: towards a whole-cell model
Reviewartikel, 2021

The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important eukaryal model organism for studying cellular physiology related to human health and disease. Yeast was also the first eukaryal organism for which a genome-scale metabolic model (GEM) was developed. In recent years there has been interest in expanding the modeling framework for yeast by incorporating enzymatic parameters and other heterogeneous cellular networks to obtain a more comprehensive description of cellular physiology. We review the latest developments in multiscale models of yeast, and illustrate how a new generation of multiscale models could significantly enhance the predictive performance and expand the applications of classical GEMs in cell factory design and basic studies of yeast physiology.

whole-cell model

S. cerevisiae

multiscale model

yeast species

Författare

Hongzhong Lu

Chalmers, Biologi och bioteknik, Systembiologi

Eduard Kerkhoven

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

BioInnovation Institute

Chalmers, Biologi och bioteknik, Systembiologi

Trends in Biotechnology

0167-7799 (ISSN)

Vol. In Press

Ämneskategorier

Bioinformatik (beräkningsbiologi)

Bioinformatik och systembiologi

Sannolikhetsteori och statistik

DOI

10.1016/j.tibtech.2021.06.010

Mer information

Senast uppdaterat

2021-08-06