Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
Journal article, 2015

Bariatric surgery is currently the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism and adiposity, we investigated the long-term effects of bariatric surgery on the microbiome of patients randomized to Roux-en-Y gastric bypass or vertical banded gastroplasty and matched for weight and fat mass loss. The two surgical procedures induced similar and durable changes on the gut microbiome that were not dependent on body mass index and resulted in altered levels of fecal and circulating metabolites compared with obese controls. By colonizing germ-free mice with stools from the patients, we demonstrated that the surgically altered microbiota promoted reduced fat deposition in recipient mice. These mice also had a lower respiratory quotient, indicating decreased utilization of carbohydrates as fuel. Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery.


Valentina Tremaroli

University of Gothenburg

Fredrik Karlsson

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Malin Werling

University of Gothenburg

Marcus Ståhlman

University of Gothenburg

P. Kovatcheva-Datchary

University of Gothenburg

Torsten Olbers

University of Gothenburg

Lars Fändriks

University of Gothenburg

Carel W le Roux

University of Gothenburg

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Fredrik Bäckhed

University of Gothenburg

Cell Metabolism

1550-4131 (ISSN)

Vol. 22 2 228-238

Subject Categories

Gastroenterology and Hepatology

Areas of Advance

Life Science Engineering (2010-2018)





More information