Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
Artikel i vetenskaplig tidskrift, 2015

Bariatric surgery is currently the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism and adiposity, we investigated the long-term effects of bariatric surgery on the microbiome of patients randomized to Roux-en-Y gastric bypass or vertical banded gastroplasty and matched for weight and fat mass loss. The two surgical procedures induced similar and durable changes on the gut microbiome that were not dependent on body mass index and resulted in altered levels of fecal and circulating metabolites compared with obese controls. By colonizing germ-free mice with stools from the patients, we demonstrated that the surgically altered microbiota promoted reduced fat deposition in recipient mice. These mice also had a lower respiratory quotient, indicating decreased utilization of carbohydrates as fuel. Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery.

Författare

Valentina Tremaroli

Göteborgs universitet

Fredrik Karlsson

Chalmers, Biologi och bioteknik, Systembiologi

Malin Werling

Göteborgs universitet

Marcus Ståhlman

Göteborgs universitet

P. Kovatcheva-Datchary

Göteborgs universitet

Torsten Olbers

Göteborgs universitet

Lars Fändriks

Göteborgs universitet

Carel W le Roux

Göteborgs universitet

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Fredrik Bäckhed

Göteborgs universitet

Cell Metabolism

1550-4131 (ISSN)

Vol. 22 2 228-238

Ämneskategorier

Gastroenterologi

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1016/j.cmet.2015.07.009

PubMed

26244932