Reframing the role of the objective function in its proper context for metabolic network modeling
Other text in scientific journal, 2025
The “objective function” is a core concept in metabolic network modeling. Its use has enabled the analysis of large data to drive deeper understanding of cellular metabolism. This commentary reframes how the objective function is discussed to enhance its value and clarify misunderstandings in metabolic network modeling.
Author
Mohammad Mazharul Islam
University of Virginia
William Shao
University of Virginia
Mariska Batavia
University of Virginia
Roseanne M. Ford
University of Virginia
B. O. Palsson
University of California
Jens B Nielsen
Chalmers, Life Sciences, Systems and Synthetic Biology
Costas D. Maranas
Penn State College of Engineering
Sang Yup Lee
Korea Advanced Institute of Science and Technology (KAIST)
J. A. Papin
University of Virginia
Cell Systems
24054712 (ISSN) 24054720 (eISSN)
Vol. 16 6 101298Subject Categories (SSIF 2025)
Cell Biology
DOI
10.1016/j.cels.2025.101298