In search for symmetries in the metabolism of cancer
Review article, 2016
Even though aerobic glycolysis, or the Warburg effect, is arguably the most common trait of metabolic reprogramming in cancer, it is unobserved in certain tumor types. Systems biology advocates a global view on metabolism to dissect which traits are consistently reprogrammed in cancer, and hence likely to constitute an obligate step for the evolution of cancer cells. We refer to such traits as symmetric. Here, we review early systems biology studies that attempted to reveal symmetric traits in the metabolic reprogramming of cancer, discuss the symmetry of reprogramming of nucleotide metabolism, and outline the current limitations that, if unlocked, could elucidate whether symmetries in cancer metabolism may be claimed.
growth
Research & Experimental Medicine
network
glucose
expression
mtor
aerobic glycolysis
glutamine-metabolism
novo pyrimidine synthesis
c-myc
cell metabolism
Author
Francesco Gatto
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Wiley Interdisciplinary Reviews: Systems Biology and Medicine
1939-5094 (ISSN) 1939-005X (eISSN)
Vol. 8 1 23-35Areas of Advance
Life Science Engineering (2010-2018)
Subject Categories
Bioinformatics and Systems Biology
DOI
10.1002/wsbm.1321