In search for symmetries in the metabolism of cancer
Journal article, 2016

Even though aerobic glycolysis, or the Warburg effect, is arguably the most common trait of metabolic reprogramming in cancer, it is unobserved in certain tumor types. Systems biology advocates a global view on metabolism to dissect which traits are consistently reprogrammed in cancer, and hence likely to constitute an obligate step for the evolution of cancer cells. We refer to such traits as symmetric. Here, we review early systems biology studies that attempted to reveal symmetric traits in the metabolic reprogramming of cancer, discuss the symmetry of reprogramming of nucleotide metabolism, and outline the current limitations that, if unlocked, could elucidate whether symmetries in cancer metabolism may be claimed.

glucose

cell metabolism

growth

network

Research & Experimental Medicine

c-myc

expression

mtor

novo pyrimidine synthesis

glutamine-metabolism

aerobic glycolysis

Author

Francesco Gatto

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

1939-5094 (ISSN) 1939-005X (eISSN)

Vol. 8 1 23-35

Areas of Advance

Life Science Engineering (2010-2018)

Subject Categories

Bioinformatics and Systems Biology

DOI

10.1002/wsbm.1321

More information

Created

10/7/2017