In search for symmetries in the metabolism of cancer
Artikel i vetenskaplig tidskrift, 2016

Even though aerobic glycolysis, or the Warburg effect, is arguably the most common trait of metabolic reprogramming in cancer, it is unobserved in certain tumor types. Systems biology advocates a global view on metabolism to dissect which traits are consistently reprogrammed in cancer, and hence likely to constitute an obligate step for the evolution of cancer cells. We refer to such traits as symmetric. Here, we review early systems biology studies that attempted to reveal symmetric traits in the metabolic reprogramming of cancer, discuss the symmetry of reprogramming of nucleotide metabolism, and outline the current limitations that, if unlocked, could elucidate whether symmetries in cancer metabolism may be claimed.

glucose

cell metabolism

growth

network

Research & Experimental Medicine

c-myc

expression

mtor

novo pyrimidine synthesis

glutamine-metabolism

aerobic glycolysis

Författare

Francesco Gatto

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

1939-5094 (ISSN) 1939-005X (eISSN)

Vol. 8 23-35

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Bioinformatik och systembiologi

DOI

10.1002/wsbm.1321