Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals
Journal article, 2015

© 2015 Elsevier Inc. Industrial bio-processes for fine chemical production are increasingly relying on cell factories developed through metabolic engineering and synthetic biology. The use of high throughput techniques and automation for the design of cell factories, and especially platform strains, has played an important role in the transition from laboratory research to industrial production. Model organisms such as Saccharomyces cerevisiae and Escherichia coli remain widely used host strains for industrial production due to their robust and desirable traits. This review describes some of the bio-based fine chemicals that have reached the market, key metabolic engineering tools that have allowed this to happen and some of the companies that are currently utilizing these technologies for developing industrial production processes.

Saccharomyces cerevisiae

Escherichia coli

Synthetic biology

Cell factories

Metabolic engineering

Industrial production

Author

David Jullesson

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Florian David

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

B. F. Pfleger

University of Wisconsin Madison

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Biotechnology Advances

0734-9750 (ISSN)

Vol. 33 7 1395-1402

Subject Categories

Industrial Biotechnology

Bioinformatics and Systems Biology

Areas of Advance

Energy

Life Science Engineering (2010-2018)

Infrastructure

C3SE (Chalmers Centre for Computational Science and Engineering)

DOI

10.1016/j.biotechadv.2015.02.011

More information

Latest update

10/15/2018