Tackling Cancer with Yeast-Based Technologies
Review article, 2019

The ability to precisely engineer yeast, coupled with its genetic and metabolic similarity to tumor cells, has enabled researchers to use this organism in cancer research. Here we review advances that leveraged yeast as a model organism for studying cancer biology, including the investigation of tumorigenic mechanisms, development of advanced technologies for drug discovery, production of anticancer drugs on an industrial scale, and delivering the next generation of immunotherapies.

SGA

immunotherapy

cancer vaccines

CRISPR

humanized antibody

metabolic engineering

Author

Raphael Ferreira

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Angelo Limeta

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Technical University of Denmark (DTU)

Trends in Biotechnology

0167-7799 (ISSN)

Vol. 37 6 592-603

Subject Categories

Medical Biotechnology

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Cancer and Oncology

DOI

10.1016/j.tibtech.2018.11.013

More information

Latest update

12/4/2019