Tackling Cancer with Yeast-Based Technologies
Reviewartikel, 2019

The ability to precisely engineer yeast, coupled with its genetic and metabolic similarity to tumor cells, has enabled researchers to use this organism in cancer research. Here we review advances that leveraged yeast as a model organism for studying cancer biology, including the investigation of tumorigenic mechanisms, development of advanced technologies for drug discovery, production of anticancer drugs on an industrial scale, and delivering the next generation of immunotherapies.

SGA

immunotherapy

cancer vaccines

CRISPR

humanized antibody

metabolic engineering

Författare

Raphael Ferreira

Chalmers, Biologi och bioteknik, Systembiologi

Angelo Limeta

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Danmarks Tekniske Universitet (DTU)

Trends in Biotechnology

0167-7799 (ISSN)

Vol. 37 6 592-603

Ämneskategorier

Medicinsk bioteknik

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Cancer och onkologi

DOI

10.1016/j.tibtech.2018.11.013

Mer information

Senast uppdaterat

2019-12-04