Heme metabolism in stress regulation and protein production: From Cinderella to a key player.
Other text in scientific journal, 2016
Heme biosynthesis is a highly conserved pathway which is present in all kingdoms, from Archaea to higher organisms such as plants and mammals. The heme molecule acts as a prosthetic group for different proteins and enzymes involved in energy metabolism and reactions involved in electron transfer. Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its regulation could impact our ability to develop more efficient yeast cell factories for heterologous protein production.
Plants
metabolism
metabolism
Heme
Archaea
biosynthesis
metabolism
Saccharomyces cerevisiae
metabolism
Saccharomyces cerevisiae Proteins
Animals
Author
Jose Luis Martinez Ruiz
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Novo Nordisk Foundation
Dina Petranovic Nielsen
Novo Nordisk Foundation
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Jens B Nielsen
Technical University of Denmark (DTU)
Novo Nordisk Foundation
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Bioengineered
2165-5979 (ISSN) 2165-5987 (eISSN)
Vol. 7 2 1-4Subject Categories
Industrial Biotechnology
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.1080/21655979.2015.1126016
PubMed
26731643