Heme metabolism in stress regulation and protein production: From Cinderella to a key player.
Journal article, 2016

Heme biosynthesis is a highly conserved pathway which is present in all kingdoms, from Archaea to higher organisms such as plants and mammals. The heme molecule acts as a prosthetic group for different proteins and enzymes involved in energy metabolism and reactions involved in electron transfer. Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its regulation could impact our ability to develop more efficient yeast cell factories for heterologous protein production.

Heme

Saccharomyces cerevisiae Proteins

metabolism

Saccharomyces cerevisiae

metabolism

biosynthesis

Archaea

metabolism

metabolism

Animals

Plants

Author

Jose Luis Martinez Ruiz

Novo Nordisk Foundation Center for Biosustainability

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Dina Petranovic Nielsen

Novo Nordisk Foundation Center for Biosustainability

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Novo Nordisk Foundation Center for Biosustainability

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Technical University of Denmark (DTU)

Bioengineered

2165-5979 (ISSN) 2165-5987 (eISSN)

Vol. 7 2 1-4

Subject Categories

Industrial Biotechnology

Areas of Advance

Life Science Engineering (2010-2018)

DOI

10.1080/21655979.2015.1126016

PubMed

26731643

More information

Latest update

7/29/2021