Dina Petranovic Nielsen

Docent at Department of Biology and Biological Engineering, Systems and Synthetic Biology

Dina Petranovic teaches molecular and cell biology and directs the group of Yeast Cell Aging and Death. The main focus of the group is to study (by experimental and computational approaches) molecular mechanisms that lead to cell aging and death. The research is of fundamental and applied relevance: the biology of aging and death is an exciting field for scientific explorations. Additionally, the fields of biotechnology and biomedicine can profit from the studies of these pathways, for example in design of robust cell factories or for testing molecular mechanisms for drug design.More information about publications and the other details:Petranovic Lab

Source: chalmers.se

Projects

2015–2019

Produktion av blodersättningsmedel

Dina Petranovic Nielsen Department of Biology and Biological Engineering, Systems and Synthetic Biology
Swedish Foundation for Strategic Research (SSF)

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Publications

2016

The impact of respiration and oxidative stress response on recombinant ?-amylase production by Saccharomyces cerevisiae

José Luis Martinez Ruiz, Eugenio Meza, Dina Petranovic et al
Metabolic Engineering Communications. Vol. 3, p. 205-210
Scientific journal article - peer reviewed
2016

Role of frameshift ubiquitin B protein in Alzheimer's disease

Xin Chen, Dina Petranovic,
Wiley Interdisciplinary Reviews: Systems Biology and Medicine. Vol. 8 (4), p. 300-313
Scientific journal article - peer reviewed
2016

PUFA-induced cell death is mediated by Yca1p-dependent and -independent pathways, and is reduced by vitamin C in yeast

Magnus Johansson, Xin Chen, Stefina Milanova et al
FEMS Yeast Research. Vol. 16 (2)
Scientific journal article - peer reviewed
2015

Improving heterologous protein secretion at aerobic conditions by activating hypoxia-induced genes in Saccharomyces cerevisiae

Lifang Liu, Yiming Zhang, Zihe Liu et al
FEMS Yeast Research. Vol. 15 (7), p. 10
Scientific journal article - peer reviewed
2015

Non-Linear Microscopy of Mitochondrial Damage and Abnormal Lipid Metabolism in Beta-Amyloid Expressing Yeast

Nisha Rani Agarwal, Xin Chen, Kumaravel Ponnandai Shunmugavel et al
Biophysical Journal. Vol. 108 (2), p. 325A-325A
Conference paper - non peer reviewed
2015

Amyloid-beta peptide-induced cytotoxicity and mitochondrial dysfunction in yeast

Xin Chen, Dina Petranovic,
Fems Yeast Research. Vol. 15 (6), p. Art. no. fov061
Scientific journal article - peer reviewed
2015

Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast

Mingtao Huang, Y. P. Bai, S. L. Sjostrom et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 112 (34), p. E4689-E4696
Scientific journal article - peer reviewed
2015

Genome-wide expression analyses of the stationary phase model of ageing in yeast

Kwanjeera Wanichthanarak, Nutvadee Wongtosrad, Dina Petranovic et al
Mechanisms of Ageing and Development. Vol. 149, p. 65-74
Scientific journal article - peer reviewed
2015

Engineering the Oxygen Sensing Regulation Results in an Enhanced Recombinant Human Hemoglobin Production by Saccharomyces cerevisiae

José Luis Martinez Ruiz, Lifang Liu, Dina Petranovic et al
Biotechnology and Bioengineering. Vol. 112 (1), p. 181-188
Scientific journal article - peer reviewed
2014

Altered sterol composition renders yeast thermotolerant

Luis Caspeta, Yun Chen, Payam Ghiaci et al
Science. Vol. 346 (6205), p. 75-78
Scientific journal article - peer reviewed
2014

Improved Production of a Heterologous Amylase in Saccharomyces cerevisiae by Inverse Metabolic Engineering

Zihe Liu, Lifang Liu, Tobias Österlund et al
Applied and Environmental Microbiology. Vol. 80 (17), p. 5542-5550
Scientific journal article - peer reviewed
2014

Altered sterol composition renders yeast thermotolerant

Luis Caspeta, Yun Chen, Payam Ghiaci et al
Science. Vol. 346 (6205), p. 75-78
Scientific journal article - peer reviewed
2014

Impact of protein uptake and degradation on recombinant protein secretion in yeast

Keith Tyo, Zihe Liu, Ylva Magnusson et al
Applied Microbiology and Biotechnology. Vol. 98 (16), p. 7149-7159
Scientific journal article - peer reviewed
2014

yStreX: yeast stress expression database

Kwanjeera Wanichthanarak, Intawat Nookaew, Dina Petranovic et al
Database-the Journal of Biological Databases and Curation
Scientific journal article - peer reviewed
2014

Management of the endoplasmic reticulum stress by activation of the heat shock response in yeast

Jin Hou, H. T. Tang, Zihe Liu et al
Fems Yeast Research. Vol. 14 (3), p. 481-494
Scientific journal article - peer reviewed
2014

Approaches to study yeast cell aging and death

M. G. Mirisola, R. J. Braun, Dina Petranovic et al
Fems Yeast Research. Vol. 14 (1), p. 109-118
Scientific journal article - peer reviewed
2014

Yeast cell aging and death

Dina Petranovic, A. Ganley,
Fems Yeast Research. Vol. 14 (1), p. 1-1
Scientific journal article - peer reviewed
2014

Balanced globin protein expression and heme biosynthesis improve production of human hemoglobin in Saccharomyces cerevisiae

Lifang Liu, José Luis Martinez Ruiz, Zihe Liu et al
Metabolic Engineering. Vol. 21, p. 9-16
Scientific journal article - peer reviewed
2013

yApoptosis: yeast apoptosis database

Kwanjeera Wanichthanarak, Marija Cvijovic, Andrea Molt et al
DATABASE - THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION . Vol. 2013 (Art. no. bat068 )
Scientific journal article - peer reviewed
2013

Correlation of cell growth and heterologous protein production by Saccharomyces cerevisiae

Zihe Liu, Jin Hou, José Luis Martinez Ruiz et al
Applied Microbiology and Biotechnology. Vol. 97 (20), p. 8955-8962
Scientific journal article - peer reviewed
2013

Anaerobic alpha-Amylase Production and Secretion with Fumarate as the Final Electron Acceptor in Saccharomyces cerevisiae

Zihe Liu, Tobias Österlund, Jin Hou et al
Applied and Environmental Microbiology. Vol. 79 (9), p. 2962-2967
Scientific journal article - peer reviewed
2013

Genome-Scale Modeling of the Protein Secretory Machinery in Yeast

Amir Feizi, Tobias Österlund, Dina Petranovic et al
PLoS ONE. Vol. 8 (5)
Scientific journal article - peer reviewed
2013

Heat shock response improves heterologous protein secretion in Saccharomyces cerevisiae

Jin Hou, Tobias Österlund, Zihe Liu et al
Applied Microbiology and Biotechnology. Vol. 97 (8), p. 3559-3568
Scientific journal article - peer reviewed
2012

Pharmaceutical protein production by yeast: towards production of human blood proteins by microbial fermentation

José Luis Martinez Ruiz, Lifang Liu, Dina Petranovic et al
Current Opinion in Biotechnology. Vol. 23 (6), p. 965-971
Scientific journal article - peer reviewed
2012

Boolean model of yeast apoptosis as a tool to study yeast and human apoptotic regulations

Laleh Kazemzadeh, Marija Cvijovic, Dina Petranovic et al
Frontiers in Physiology. Vol. 3
Scientific journal article - peer reviewed
2012

Symptomatic atherosclerosis is associated with an altered gut metagenome

Fredrik H. Karlsson, Frida Fåk, Intawat Nookaew et al
Nature Communications. Vol. 3
Scientific journal article - peer reviewed
2012

Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae

Jin Hou, Keith Tyo, Zihe Liu et al
Fems Yeast Research. Vol. 12 (5), p. 491-510
Scientific journal article - peer reviewed
2012

Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae

Zihe Liu, Keith Tyo, José Luis Martinez Ruiz et al
Biotechnology and Bioengineering. Vol. 109 (5), p. 1259-1268
Scientific journal article - peer reviewed
2012

Engineering of vesicle trafficking improves heterologous protein secretion in Saccharomyces cerevisiae

Jin Hou, Keith Tyo, Zihe Liu et al
Metabolic Engineering. Vol. 14 (2), p. 120-127
Scientific journal article - peer reviewed
2012

Systems biology of yeast cell death

Ana Joyce Muñoz, Kwanjeera Wanichthanarak, Eugenio Meza et al
Fems Yeast Research. Vol. 12 (2), p. 249-265
Scientific journal article - peer reviewed
2012

Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress

Keith Tyo, Zihe Liu, Dina Petranovic et al
BMC Biology. Vol. 10 (16), p. Art. no 16
Scientific journal article - peer reviewed
2011

Prospects for systems biology and modeling of the gut microbiome

Fredrik H. Karlsson, Intawat Nookaew, Dina Petranovic et al
Trends in Biotechnology. Vol. 29 (6), p. 251-258
Scientific journal article - peer reviewed
2011

Heterologous production of polyunsaturated fatty acids in Saccharomyces cerevisiae causes a global transcriptional response resulting in reduced proteasomal activity and increased oxidative stress

R. Ruenwai, A. Neiss, K. Laoteng et al
Biotechnology Journal. Vol. 6 (3), p. 343-356
Scientific journal article - peer reviewed
2010

Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains

A. B. Canelas, N. Harrison, A. Fazio et al
Nature Communications. Vol. 1
Scientific journal article - peer reviewed
2010

Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism

Dina Petranovic, Keith Tyo, Goutham N. Vemuri et al
Fems Yeast Research. Vol. 10 (8), p. 1046-1059
Scientific journal article - peer reviewed
2010

Phosphoglycerate Mutase Is a Highly Efficient Enzyme without Flux Control in Lactococcus lactis

C. Solem, Dina Petranovic, B. Koebmann et al
Journal of Molecular Microbiology and Biotechnology. Vol. 18 (3), p. 174-180
Scientific journal article - peer reviewed
2009

Impact of yeast systems biology on industrial biotechnology

Dina Petranovic, Goutham N. Vemuri,
Journal of Biotechnology. Vol. 144 (3), p. 204-211
Scientific journal article - peer reviewed
2008

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

Markus J Herrgård, Neil Swainston, Paul Dobson et al
Nature Biotechnology. Vol. 26 (10), p. 1155-1160
Scientific journal article - peer reviewed
2008

Can yeast systems biology contribute to the understanding of human disease?

Dina Petranovic, Jens B. Nielsen,
Trends in Biotechnology. Vol. 26 (11), p. 584-590
Scientific journal article - peer reviewed