Dina Petranovic Nielsen

Docent at Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Dina Petranovic teaches molecular and cell biology and directs the group of Yeast Cell Aging and Death. The main focus of the group is to study (by experimental and computational approaches) molecular mechanisms that lead to cell aging and death. The research is of fundamental and applied relevance: the biology of aging and death is an exciting field for scientific explorations. Additionally, the fields of biotechnology and biomedicine can profit from the studies of these pathways, for example in design of robust cell factories or for testing molecular mechanisms for drug design.More information about publications and the other details:Petranovic Lab

Source: chalmers.se

Projects

2015–2019

Produktion av blodersättningsmedel

Dina Petranovic Nielsen Systems and Synthetic Biology
Swedish Foundation for Strategic Research (SSF)

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Publications

2017

Moderate Expression of SEC16 Increases Protein Secretion by Saccharomyces cerevisiae

Dina Petranovic Nielsen, Jichen Bao, Jens B Nielsen et al
Applied and Environmental Microbiology. Vol. 83 (14), p. Article no. UNSP e03400-16
Journal article
2017

Probing functional roles of Wilson disease protein (ATP7B) copper-binding domains in yeast

Kumaravel Ponnandai Shanmugavel, Dina Petranovic Nielsen, Pernilla Wittung Stafshede
Metallomics. Vol. 9 (7), p. 981-988
Journal article
2017

Interplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-beta (A beta) Toxicity in Yeast

Mark Bisschops, Dina Petranovic Nielsen, Boyang Ji et al
Frontiers in Molecular Neuroscience. Vol. 10
Journal article
2016

The impact of respiration and oxidative stress response on recombinant ?-amylase production by Saccharomyces cerevisiae

Jose Luis Martinez Ruiz, Dina Petranovic Nielsen, Jens B Nielsen et al
Metabolic Engineering Communications. Vol. 3, p. 205-210
Journal article
2016

Role of frameshift ubiquitin B protein in Alzheimer's disease

Xin Chen, Dina Petranovic Nielsen
Wiley Interdisciplinary Reviews: Systems Biology and Medicine. Vol. 8 (4), p. 300-313
Journal article
2016

PUFA-induced cell death is mediated by Yca1p-dependent and -independent pathways, and is reduced by vitamin C in yeast

Stefina Milanova, Xin Chen, Cristiano Santos et al
FEMS Yeast Research. Vol. 16 (2)
Journal article
2016

Heme metabolism in stress regulation and protein production: From Cinderella to a key player.

Dina Petranovic Nielsen, Jens B Nielsen, Jose Luis Martinez Ruiz
Bioengineered Bugs. Vol. 7 (2), p. 112-5
Journal article
2016

Bacillus subtilis single-stranded DNA-binding protein SsbA is phosphorylated at threonine 38 by the serine/threonine kinase YabT

Abderahmane Derouiche, Ivan Mijakovic, Dina Petranovic Nielsen et al
Periodicum Biologorum. Vol. 118 (4), p. 399-404
Journal article
2016

Characterization of physiological and transcriptional properties of improved protein secretion yeast strains

Jens B Nielsen, Mingtao Huang, Jichen Bao et al
11th Metabolic Engineering Conference 2016; Awaji Island; Japan, p. 639-640
Conference contribution
2015

Genome-wide expression analyses of the stationary phase model of ageing in yeast

Kwanjeera Wanichthanarak, Dina Petranovic Nielsen, Nutvadee Wongtosrad
Mechanisms of Ageing and Development. Vol. 149, p. 65-74
Journal article
2015

Amyloid-beta peptide-induced cytotoxicity and mitochondrial dysfunction in yeast

Dina Petranovic Nielsen, Xin Chen
FEMS Yeast Research. Vol. 15 (6), p. Art. no. fov061-
Journal article
2015

Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast

S. L. Sjostrom, Mingtao Huang, M. Uhlen et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 112 (34), p. E4689-E4696
Journal article
2015

Engineering the Oxygen Sensing Regulation Results in an Enhanced Recombinant Human Hemoglobin Production by Saccharomyces cerevisiae

Jens B Nielsen, Dina Petranovic Nielsen, Lifang Liu et al
Biotechnology and Bioengineering. Vol. 112 (1), p. 181-188
Journal article
2015

Improving heterologous protein secretion at aerobic conditions by activating hypoxia-induced genes in Saccharomyces cerevisiae

Dina Petranovic Nielsen, Lifang Liu, Yiming Zhang et al
FEMS Yeast Research. Vol. 15 (7), p. 10-
Journal article
2015

Non-Linear Microscopy of Mitochondrial Damage and Abnormal Lipid Metabolism in Beta-Amyloid Expressing Yeast

Nisha Rani Agarwal, Xin Chen, Dina Petranovic Nielsen et al
Biophysical Journal. Vol. 108 (2), p. 325A-325A
Conference contribution
2014

Approaches to study yeast cell aging and death

M. G. Mirisola, Dina Petranovic Nielsen, R. J. Braun
FEMS Yeast Research. Vol. 14 (1), p. 109-118
Journal article
2014

Yeast cell aging and death

Dina Petranovic Nielsen, A. Ganley
FEMS Yeast Research. Vol. 14 (1), p. 1-1
Journal article
2014

Management of the endoplasmic reticulum stress by activation of the heat shock response in yeast

Jens B Nielsen, Tobias Österlund, Zihe Liu et al
FEMS Yeast Research. Vol. 14 (3), p. 481-494
Journal article
2014

Altered sterol composition renders yeast thermotolerant

Luis Caspeta-Guadarrama, B. M. Hallstrom, Steen Buskov et al
Science. Vol. 346 (6205), p. 75-78
Journal article
2014

yStreX: yeast stress expression database

Dina Petranovic Nielsen, Kwanjeera Wanichthanarak, Intawat Nookaew
Database : the journal of biological databases and curation
Journal article
2014

Impact of protein uptake and degradation on recombinant protein secretion in yeast

Dina Petranovic Nielsen, Jens B Nielsen, Ylva Magnusson et al
Applied Microbiology and Biotechnology. Vol. 98 (16), p. 7149-7159
Journal article
2014

Balanced globin protein expression and heme biosynthesis improve production of human hemoglobin in Saccharomyces cerevisiae

Lifang Liu, Zihe Liu, Jose Luis Martinez Ruiz et al
Metabolic Engineering. Vol. 21, p. 9-16
Journal article
2014

Improved Production of a Heterologous Amylase in Saccharomyces cerevisiae by Inverse Metabolic Engineering

Jens B Nielsen, Mingtao Huang, Zihe Liu et al
Applied and Environmental Microbiology. Vol. 80 (17), p. 5542-5550
Journal article
2013

Anaerobic alpha-Amylase Production and Secretion with Fumarate as the Final Electron Acceptor in Saccharomyces cerevisiae

Jin Hou, Jens B Nielsen, Zihe Liu et al
Applied and Environmental Microbiology. Vol. 79 (9), p. 2962-2967
Journal article
2013

Genome-Scale Modeling of the Protein Secretory Machinery in Yeast

Amir Feizi, Dina Petranovic Nielsen, Jens B Nielsen et al
PLoS ONE. Vol. 8 (5)
Journal article
2013

yApoptosis: yeast apoptosis database

Dina Petranovic Nielsen, Marija Cvijovic, Andrea Molt et al
Database : the journal of biological databases and curation. Vol. 2013 (Art. no. bat068)
Journal article
2013

Heat shock response improves heterologous protein secretion in Saccharomyces cerevisiae

Dina Petranovic Nielsen, Jens B Nielsen, Zihe Liu et al
Applied Microbiology and Biotechnology. Vol. 97 (8), p. 3559-3568
Journal article
2013

Correlation of cell growth and heterologous protein production by Saccharomyces cerevisiae

Jens B Nielsen, Dina Petranovic Nielsen, Zihe Liu et al
Applied Microbiology and Biotechnology. Vol. 97 (20), p. 8955-8962
Journal article
2012

Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress

Dina Petranovic Nielsen, Keith Tyo, Zihe Liu et al
BMC Biology. Vol. 10 (16), p. Art. no 16-
Journal article
2012

Pharmaceutical protein production by yeast: towards production of human blood proteins by microbial fermentation

Jose Luis Martinez Ruiz, Jens B Nielsen, Dina Petranovic Nielsen et al
Current Opinion in Biotechnology. Vol. 23 (6), p. 965-971
Journal article
2012

Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae

Dina Petranovic Nielsen, Jens B Nielsen, Jin Hou et al
FEMS Yeast Research. Vol. 12 (5), p. 491-510
Journal article
2012

Symptomatic atherosclerosis is associated with an altered gut metagenome

Valentina Tremaroli, Intawat Nookaew, Fredrik Karlsson et al
Nature Communications. Vol. 3
Journal article
2012

Systems biology of yeast cell death

Eugenio Meza, Dina Petranovic Nielsen, Ana Joyce Muñoz Arellano et al
FEMS Yeast Research. Vol. 12 (2), p. 249-265
Journal article
2012

Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae

Keith Tyo, Jose Luis Martinez Ruiz, Dina Petranovic Nielsen et al
Biotechnology and Bioengineering. Vol. 109 (5), p. 1259-1268
Journal article
2012

Engineering of vesicle trafficking improves heterologous protein secretion in Saccharomyces cerevisiae

Keith Tyo, Jens B Nielsen, Zihe Liu et al
Metabolic Engineering. Vol. 14 (2), p. 120-127
Journal article
2012

Boolean model of yeast apoptosis as a tool to study yeast and human apoptotic regulations

Laleh Kazemzadeh, Dina Petranovic Nielsen, Marija Cvijovic
Frontiers in Physiology. Vol. 3
Journal article
2011

Prospects for systems biology and modeling of the gut microbiome

Dina Petranovic Nielsen, Fredrik Karlsson, Intawat Nookaew et al
Trends in Biotechnology. Vol. 29 (6), p. 251-258
Journal article
2010

Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains

J. van den Brink, B.M. Bakker, Dina Petranovic Nielsen et al
Nature Communications. Vol. 1 (9)
Journal article
2010

Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism

Dina Petranovic Nielsen, Goutham Vemuri, Keith Tyo et al
FEMS Yeast Research. Vol. 10 (8), p. 1046-1059
Journal article
2010

Phosphoglycerate Mutase Is a Highly Efficient Enzyme without Flux Control in Lactococcus lactis

P. R. Jensen, B. Koebmann, C. Solem et al
Journal of Molecular Microbiology and Biotechnology. Vol. 18 (3), p. 174-180
Journal article
2009

Impact of yeast systems biology on industrial biotechnology

Goutham Vemuri, Dina Petranovic Nielsen
Journal of Biotechnology. Vol. 144 (3), p. 204-211
Journal article
2008

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

Paul Dobson, Roger Brent, Evangelos Simeonidis et al
Nature Biotechnology. Vol. 26 (10), p. 1155-1160
Journal article
2008

Can yeast systems biology contribute to the understanding of human disease?

Dina Petranovic Nielsen, Jens B Nielsen
Trends in Biotechnology. Vol. 26 (11), p. 584-590
Journal article