Prospects for systems biology and modeling of the gut microbiome
Journal article, 2011
Abundant microorganisms that inhabit the human intestine are implicated in health and disease. The gut microbiome has been studied with metagenomic tools, and over 3 million genes have been discovered, constituting a 'parts list' of this ecosystem; further understanding requires studies of the interacting parts. Mouse models have provided a glimpse into the microbiota and host interactions at metabolic and immunologic levels; however, to provide more insight, there is a need to generate mathematical models that can reveal genotype-phenotype relationships and provide scaffolds for integrated analyses. To this end, we propose the use of genome-scale metabolic models that have successfully been used in studying interactions between human hosts and microbes, as well as microbes in isolation and in communities.
metabolic
butyrate
bacterial mutualism
receptor
diet-induced obesity
chain fatty-acids
human colonic microbiota
protein-coupled
reconstruction
networks
high-throughput
inflammatory bowel diseases
Author
Fredrik Karlsson
Chalmers, Chemical and Biological Engineering, Life Sciences
Intawat Nookaew
Chalmers, Chemical and Biological Engineering, Life Sciences
Dina Petranovic Nielsen
Chalmers, Chemical and Biological Engineering, Life Sciences
Jens B Nielsen
Chalmers, Chemical and Biological Engineering, Life Sciences
Trends in Biotechnology
0167-7799 (ISSN) 18793096 (eISSN)
Vol. 29 6 251-258Subject Categories
Industrial Biotechnology
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.1016/j.tibtech.2011.01.009