Systems biology of yeast cell death
Journal article, 2012
Programmed cell death (PCD) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. Yeast Saccharomyces cerevisiae, a unicellular eukaryotic organism, shares with multicellular organisms (including humans) key components and regulators of the PCD machinery. In this article, we review the current state of knowledge about cell death networks, including the modeling approaches and experimental strategies commonly used to study yeast cell death. We argue that the systems biology approach will bring valuable contributions to our understanding of regulations and mechanisms of the complex cell death pathways.
promotes apoptosis
fluorescent-probes
hydrogen-peroxide
caspase
activation
signaling networks
saccharomyces-cerevisiae
rat-liver mitochondria
yeast
dna
molecular-mechanisms
apoptosis systems biology
programmed cell death
fragmentation
bcl-2 protein family