Systems biology of yeast cell death
Review article, 2012
Programmed cell death (PCD) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. Yeast Saccharomyces cerevisiae, a unicellular eukaryotic organism, shares with multicellular organisms (including humans) key components and regulators of the PCD machinery. In this article, we review the current state of knowledge about cell death networks, including the modeling approaches and experimental strategies commonly used to study yeast cell death. We argue that the systems biology approach will bring valuable contributions to our understanding of regulations and mechanisms of the complex cell death pathways.
molecular-mechanisms
bcl-2 protein family
signaling networks
rat-liver mitochondria
fragmentation
caspase
activation
apoptosis systems biology
programmed cell death
saccharomyces-cerevisiae
fluorescent-probes
hydrogen-peroxide
yeast
dna
promotes apoptosis
Author
Ana Joyce Muñoz Arellano
Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology
Kwanjeera Wanichthanarak
Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology
Eugenio Meza
Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology
Dina Petranovic Nielsen
Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology
FEMS Yeast Research
1567-1356 (ISSN) 1567-1364 (eISSN)
Vol. 12 2 249-265Subject Categories
Industrial Biotechnology
Bioinformatics and Systems Biology
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.1111/j.1567-1364.2011.00781.x