Systems biology of yeast cell death
Reviewartikel, 2012
Programmed cell death (PCD) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. Yeast Saccharomyces cerevisiae, a unicellular eukaryotic organism, shares with multicellular organisms (including humans) key components and regulators of the PCD machinery. In this article, we review the current state of knowledge about cell death networks, including the modeling approaches and experimental strategies commonly used to study yeast cell death. We argue that the systems biology approach will bring valuable contributions to our understanding of regulations and mechanisms of the complex cell death pathways.
molecular-mechanisms
bcl-2 protein family
signaling networks
rat-liver mitochondria
fragmentation
caspase
activation
apoptosis systems biology
programmed cell death
saccharomyces-cerevisiae
fluorescent-probes
hydrogen-peroxide
yeast
dna
promotes apoptosis
Författare
Ana Joyce Muñoz Arellano
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Kwanjeera Wanichthanarak
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Eugenio Meza
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Dina Petranovic Nielsen
Chalmers, Kemi- och bioteknik, Livsvetenskaper
FEMS Yeast Research
1567-1356 (ISSN) 1567-1364 (eISSN)
Vol. 12 2 249-265Ämneskategorier (SSIF 2011)
Industriell bioteknik
Bioinformatik och systembiologi
Styrkeområden
Livsvetenskaper och teknik (2010-2018)
DOI
10.1111/j.1567-1364.2011.00781.x