Systems biology of yeast cell death
Artikel i vetenskaplig tidskrift, 2012
Programmed cell death (PCD) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. Yeast Saccharomyces cerevisiae, a unicellular eukaryotic organism, shares with multicellular organisms (including humans) key components and regulators of the PCD machinery. In this article, we review the current state of knowledge about cell death networks, including the modeling approaches and experimental strategies commonly used to study yeast cell death. We argue that the systems biology approach will bring valuable contributions to our understanding of regulations and mechanisms of the complex cell death pathways.
promotes apoptosis
fluorescent-probes
hydrogen-peroxide
caspase
activation
signaling networks
saccharomyces-cerevisiae
rat-liver mitochondria
yeast
dna
molecular-mechanisms
apoptosis systems biology
programmed cell death
fragmentation
bcl-2 protein family
Författare
Ana Joyce Muñoz Arellano
Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi
Kwanjeera Wanichthanarak
Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi
Eugenio Meza
Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi
Dina Petranovic Nielsen
Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi
FEMS Yeast Research
1567-1356 (ISSN) 1567-1364 (eISSN)
Vol. 12 2 249-265Ämneskategorier
Industriell bioteknik
Bioinformatik och systembiologi
Styrkeområden
Livsvetenskaper och teknik (2010-2018)
DOI
10.1111/j.1567-1364.2011.00781.x