Symptomatic atherosclerosis is associated with an altered gut metagenome
Journal article, 2012

Recent findings have implicated the gut microbiota as a contributor of metabolic diseases through the modulation of host metabolism and inflammation. Atherosclerosis is associated with lipid accumulation and inflammation in the arterial wall, and bacteria have been suggested as a causative agent of this disease. Here we use shotgun sequencing of the gut metagenome to demonstrate that the genus Collinsella was enriched in patients with symptomatic atherosclerosis, defined as stenotic atherosclerotic plaques in the carotid artery leading to cerebrovascular events, whereas Roseburia and Eubacterium were enriched in healthy controls. Further characterization of the functional capacity of the metagenomes revealed that patient gut metagenomes were enriched in genes encoding peptidoglycan synthesis and depleted in phytoene dehydrogenase; patients also had reduced serum levels of β-carotene. Our findings suggest that the gut metagenome is associated with the inflammatory status of the host and patients with symptomatic atherosclerosis harbor characteristic changes in the gut metagenome.

Author

Fredrik Karlsson

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Frida Fåk

University of Gothenburg

Intawat Nookaew

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Valentina Tremaroli

University of Gothenburg

Björn Fagerberg

University of Gothenburg

Dina Petranovic Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Fredrik Bäckhed

University of Gothenburg

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Nature Communications

2041-1723 (ISSN)

Vol. 3 31245

Subject Categories

Industrial Biotechnology

Areas of Advance

Life Science Engineering (2010-2018)

DOI

10.1038/ncomms2266

More information

Created

10/7/2017