Heme metabolism in stress regulation and protein production: From Cinderella to a key player.
Artikel i vetenskaplig tidskrift, 2016

Heme biosynthesis is a highly conserved pathway which is present in all kingdoms, from Archaea to higher organisms such as plants and mammals. The heme molecule acts as a prosthetic group for different proteins and enzymes involved in energy metabolism and reactions involved in electron transfer. Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its regulation could impact our ability to develop more efficient yeast cell factories for heterologous protein production.

Heme

Saccharomyces cerevisiae Proteins

metabolism

Saccharomyces cerevisiae

metabolism

biosynthesis

Archaea

metabolism

metabolism

Animals

Plants

Författare

Jose Luis Martinez Ruiz

Novo Nordisk Foundation Center for Biosustainability

Chalmers, Biologi och bioteknik, Systembiologi

Dina Petranovic Nielsen

Novo Nordisk Foundation Center for Biosustainability

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Novo Nordisk Foundation Center for Biosustainability

Chalmers, Biologi och bioteknik, Systembiologi

Danmarks Tekniske Universitet (DTU)

Bioengineered

2165-5979 (ISSN) 2165-5987 (eISSN)

Vol. 7 2 1-4

Ämneskategorier

Industriell bioteknik

Styrkeområden

Livsvetenskaper och teknik (2010-2018)

DOI

10.1080/21655979.2015.1126016

PubMed

26731643

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Senast uppdaterat

2021-07-29