Toward systems metabolic engineering of Aspergillus and Pichia species for the production of chemicals and biofuels
Review article, 2013

Recently genome sequence data have become available for Aspergillus and Pichia species of industrial interest. This has stimulated the use of systems biology approaches for large-scale analysis of the molecular and metabolic responses of Aspergillus and Pichia under defined conditions, which has resulted in much new biological information. Case-specific contextualization of this information has been performed using comparative and functional genomic tools. Genomics data are also the basis for constructing genome-scale metabolic models, and these models have helped in the contextualization of knowledge on the fundamental biology of Aspergillus and Pichia species. Furthermore, with the availability of these models, the engineering of Aspergillus and Pichia is moving from traditional approaches, such as random mutagenesis, to a systems metabolic engineering approach. Here we review the recent trends in systems biology of Aspergillus and Pichia species, highlighting the relevance of these developments for systems metabolic engineering of these organisms for the production of hydrolytic enzymes, biofuels and chemicals from biomass.



Genome-scale metabolic models (GEMs)

Aspergillus and Pichia species

Systems metabolic engineering


Luis Caspeta-Guadarrama

Chalmers, Chemical and Biological Engineering, Life Sciences

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences

Biotechnology journal

1860-6768 (ISSN) 1860-7314 (eISSN)

Vol. 8 5 534-544

Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO)

European Commission (EC) (EC/FP7/247013), 2010-01-01 -- 2014-12-31.

Driving Forces

Sustainable development

Subject Categories

Biochemistry and Molecular Biology

Areas of Advance


Life Science Engineering (2010-2018)



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