Coupling cell division to metabolic pathways through transcription
Book chapter, 2019
Cellular growth is ensured by alternation of DNA duplication and cell division cycles. This alternation is coordinated by the interplay between enzymatic activities, called kinases, and transcription factors, to keep the cell cycle timing. Here we investigate whether transcription factors may serve as hubs connecting multi-scale cellular networks. A variant of chromatin immunoprecipitation, called ChIP-exo, was performed to identify targets of Forkhead (Fkh) transcription factors across the budding yeast genome. Data analyses indicate that the Fkh-mediated transcriptional program may activate metabolic pathways and synchronize kinase activities to guarantee alternation of DNA duplication and cell division, thereby a timely cell’s cycling.
ChIP-seq
ChIP-exo
Forkhead (Fkh) transcription factors
Cell cycle
Gene expression
Data analysis
Transcriptional regulation
Metabolism
Budding yeast
Chromatin immunoprecipitation (ChIP)
Author
Petter Holland
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Thierry D.G.A. Mondeel
University of Amsterdam
Matteo Barberis
University of Amsterdam
Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics
74-93
9780128114322 (ISBN)
Subject Categories (SSIF 2011)
Cell Biology
Cell and Molecular Biology
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
DOI
10.1016/B978-0-323-95502-7.00375-4