Coupling cell division to metabolic pathways through transcription
Book chapter, 2018

Cellular growth is ensured by alternation of DNA duplication and cell division cycles. This alternation is coordinated by the interplay between enzymatic activities, called kinases, and transcription factors, to keep the cell cycle timing. Here we investigate whether transcription factors may serve as hubs connecting multi-scale cellular networks. A variant of chromatin immunoprecipitation, called ChIP-exo, was performed to identify targets of Forkhead (Fkh) transcription factors across the budding yeast genome. Data analyses indicate that the Fkh-mediated transcriptional program may activate metabolic pathways and synchronize kinase activities to guarantee alternation of DNA duplication and cell division, thereby a timely cell’s cycling.

Gene expression

Budding yeast

Forkhead (Fkh) transcription factors

Transcriptional regulation

Metabolism

Cell cycle

Data analysis

ChIP-exo

ChIP-seq

Chromatin immunoprecipitation (ChIP)

Author

Petter Holland

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Thierry D.G.A. Mondeel

University of Amsterdam

Matteo Barberis

University of Amsterdam

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics

74-93

Subject Categories

Cell Biology

Cell and Molecular Biology

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

DOI

10.1016/B978-0-12-809633-8.20081-2

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Latest update

5/7/2020 1