Coupling cell division to metabolic pathways through transcription
Kapitel i bok, 2018

Cellular growth is ensured by alternation of DNA duplication and cell division cycles. This alternation is coordinated by the interplay between enzymatic activities, called kinases, and transcription factors, to keep the cell cycle timing. Here we investigate whether transcription factors may serve as hubs connecting multi-scale cellular networks. A variant of chromatin immunoprecipitation, called ChIP-exo, was performed to identify targets of Forkhead (Fkh) transcription factors across the budding yeast genome. Data analyses indicate that the Fkh-mediated transcriptional program may activate metabolic pathways and synchronize kinase activities to guarantee alternation of DNA duplication and cell division, thereby a timely cell’s cycling.

Gene expression

Budding yeast

Forkhead (Fkh) transcription factors

Transcriptional regulation

Metabolism

Cell cycle

Data analysis

ChIP-exo

ChIP-seq

Chromatin immunoprecipitation (ChIP)

Författare

Petter Holland

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Thierry D.G.A. Mondeel

Universiteit Van Amsterdam

Matteo Barberis

Universiteit Van Amsterdam

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics

74-93

Ämneskategorier

Cellbiologi

Cell- och molekylärbiologi

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

DOI

10.1016/B978-0-12-809633-8.20081-2

Mer information

Senast uppdaterat

2020-05-07