The Impact of Systems Biology on Bioprocessing
Journal article, 2017

Bioprocessing offers a sustainable and green approach to the production of chemicals. However, a bottleneck in introducing bioprocesses is cell factory development, which is costly and time-consuming. A systems biology approach can expedite cell factory design by using genome-wide analyses alongside mathematical modeling to characterize and predict cellular physiology. This approach can drive cycles of design, build, test, and learn implemented by metabolic engineers to optimize the cell factory performance. Streamlining of the design phase requires a clearer understanding of metabolism and its regulation, which can be achieved using quantitative and integrated omic characterization, alongside more advanced analytical methods. We discuss here the current impact of systems biology and challenges of closing the gap between bioprocessing and more traditional methods of chemical production.

acid

corynebacterium-glutamicum

red macroalgae

engineered escherichia-coli

chemical production

rna-seq

saccharomyces-cerevisiae

genome-scale models

synthetic biology

yeast

Author

Kate Campbell

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jianye Xia

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Trends in Biotechnology

0167-7799 (ISSN)

Vol. 35 12 1156-1168

Subject Categories

Bioinformatics and Systems Biology

DOI

10.1016/j.tibtech.2017.08.011

More information

Latest update

5/29/2018