Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism
Journal article, 2017

The genomic era has revolutionized research on secondary metabolites and bioinformatics methods have in recent years revived the antibiotic discovery process after decades with only few new active molecules being identified. New computational tools are driven by genomics and metabolomics analysis, and enables rapid identification of novel secondary metabolites. To translate this increased discovery rate into industrial exploitation, it is necessary to integrate secondary metabolite pathways in the metabolic engineering process. In this review, we will describe the novel advances in discovery of secondary metabolites produced by filamentous fungi, highlight the utilization of genome-scale metabolic models (GEMs) in the design of fungal cell factories for the production of secondary metabolites and review strategies for optimizing secondary metabolite production through the construction of high yielding platform cell factories.

Secondary metabolism

Fungi

Genome mining

Biosynthetic gene clusters

metabolic modeling

cell factories

Author

Jens Christian Froslev Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Synthetic and Systems Biotechnology

2405-805X (eISSN)

Vol. 2 1 5-12

Roots

Basic sciences

Driving Forces

Innovation and entrepreneurship

Areas of Advance

Life Science Engineering (2010-2018)

Subject Categories

Bioinformatics and Systems Biology

DOI

10.1016/j.synbio.2017.02.002

More information

Latest update

5/29/2018