The pan-genome of Saccharomyces cerevisiae
Journal article, 2019

Understanding genotype-phenotype relationship is fundamental in biology. With the benefit from next-generation sequencing and high-throughput phenotyping methodologies, there have been generated much genome and phenome data for Saccharomyces cerevisiae. This makes it an excellent model system to understand the genotype-phenotype relationship. In this paper, we presented the reconstruction and application of the yeast pan-genome in resolving genotype-phenotype relationship by a machine learning-assisted approach.

pan-genome

Saccharomyces cerevisiae

genotype–phenotype relationship

machine learning

Author

Gang Li

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Boyang Ji

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Technical University of Denmark (DTU)

FEMS Yeast Research

1567-1356 (ISSN) 1567-1364 (eISSN)

Vol. 19 7

Subject Categories

Transport Systems and Logistics

Bioinformatics (Computational Biology)

Bioinformatics and Systems Biology

DOI

10.1093/femsyr/foz064

PubMed

31584649

More information

Latest update

11/12/2019