Genome-Scale Metabolic Modeling from Yeast to Human Cell Models of Complex Diseases: Latest Advances and Challenges
Book chapter, 2019
Genome-scale metabolic models (GEMs) are mathematical models that enable systematic analysis of metabolism. This modeling concept has been applied to study the metabolism of many organisms including the eukaryal model organism, the yeast Saccharomyces cerevisiae, that also serves as an important cell factory for production of fuels and chemicals. With the application of yeast GEMs, our knowledge of metabolism is increasing. Therefore, GEMs have also been used for modeling human cells to study metabolic diseases. Here we introduce the concept of GEMs and provide a protocol for reconstructing GEMs. Besides, we show the historic development of yeast GEMs and their applications. Also, we review human GEMs as well as their uses in the studies of complex diseases.
Saccharomyces cerevisiae
Yeast
Biomarker
Metabolic engineering
Human cells
Systems biology
Drug target
Genome-scale metabolic models
Author
Yu Chen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Gang Li
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Novo Nordisk Foundation
Jens B Nielsen
Technical University of Denmark (DTU)
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Methods in Molecular Biology
10643745 (ISSN) 1940-6029 (eISSN)
Vol. 2049 329-345Subject Categories
Medical Biotechnology
Bioinformatics (Computational Biology)
Software Engineering
DOI
10.1007/978-1-4939-9736-7_19
PubMed
31602620