Genome-Scale Metabolic Modeling from Yeast to Human Cell Models of Complex Diseases: Latest Advances and Challenges
Artikel i vetenskaplig tidskrift, 2019

Genome-scale metabolic models (GEMs) are mathematical models that enable systematic analysis of metabolism. This modeling concept has been applied to study the metabolism of many organisms including the eukaryal model organism, the yeast Saccharomyces cerevisiae, that also serves as an important cell factory for production of fuels and chemicals. With the application of yeast GEMs, our knowledge of metabolism is increasing. Therefore, GEMs have also been used for modeling human cells to study metabolic diseases. Here we introduce the concept of GEMs and provide a protocol for reconstructing GEMs. Besides, we show the historic development of yeast GEMs and their applications. Also, we review human GEMs as well as their uses in the studies of complex diseases.

Metabolic engineering

Drug target

Genome-scale metabolic models

Human cells

Saccharomyces cerevisiae



Systems biology


Yu Chen

Chalmers, Biologi och bioteknik, Systembiologi

Gang Li

Chalmers, Biologi och bioteknik, Systembiologi

Novo Nordisk Foundation Center for Biosustainability

Jens B Nielsen

Danmarks Tekniske Universitet (DTU)

Chalmers, Biologi och bioteknik, Systembiologi

Methods in molecular biology (Clifton, N.J.)

19406029 (eISSN)

Vol. 2049 329-345


Medicinsk bioteknik

Bioinformatik (beräkningsbiologi)






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