Genome-Scale Metabolic Modeling from Yeast to Human Cell Models of Complex Diseases: Latest Advances and Challenges
Kapitel i bok, 2019

Genome-scale metabolic models (GEMs) are mathematical models that enable systematic analysis of metabolism. This modeling concept has been applied to study the metabolism of many organisms including the eukaryal model organism, the yeast Saccharomyces cerevisiae, that also serves as an important cell factory for production of fuels and chemicals. With the application of yeast GEMs, our knowledge of metabolism is increasing. Therefore, GEMs have also been used for modeling human cells to study metabolic diseases. Here we introduce the concept of GEMs and provide a protocol for reconstructing GEMs. Besides, we show the historic development of yeast GEMs and their applications. Also, we review human GEMs as well as their uses in the studies of complex diseases.

Yeast

Systems biology

Human cells

Drug target

Saccharomyces cerevisiae

Metabolic engineering

Genome-scale metabolic models

Biomarker

Författare

Yu Chen

Chalmers, Biologi och bioteknik, Systembiologi

Gang Li

Chalmers, Biologi och bioteknik, Systembiologi

Novo Nordisk Foundation Center for Biosustainability

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Danmarks Tekniske Universitet (DTU)

Methods in Molecular Biology

329-345

Ämneskategorier

Medicinsk bioteknik

Bioinformatik (beräkningsbiologi)

Programvaruteknik

DOI

10.1007/978-1-4939-9736-7_19

PubMed

31602620

Mer information

Senast uppdaterat

2021-06-02