Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
Journal article, 2017

Protein secretory pathway in eukaryal cells is responsible for delivering functional secretory proteins. The dysfunction of this pathway causes a range of important human diseases from congenital disorders to cancer. Despite the piled-up knowledge on the molecular biology and biochemistry level, the tissue-specific expression of the secretory pathway genes has not been analyzed on the transcriptome level. Based on the recent RNA-sequencing studies, the largest fraction of tissue-specific transcriptome encodes for the secretome (secretory proteins). Here, the question arises that if the expression levels of the secretory pathway genes have a tissue-specific tuning. In this study, we tackled this question by performing a meta-analysis of the recently published transcriptome data on human tissues. As a result, we detected 68 as called “extreme genes” which show an unusual expression pattern in specific gene families of the secretory pathway. We also inspected the potential functional link between detected extreme genes and the corresponding tissues enriched secretome. As a result, the detected extreme genes showed correlation with the enrichment of the nature and number of specific post-translational modifications in each tissue’s secretome. Our findings conciliate both the housekeeping and tissue-specific nature of the protein secretory pathway, which we attribute to a fine-tuned regulation of defined gene families to support the diversity of secreted proteins and their modifications.

Author

Amir Feizi

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Francesco Gatto

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Mathias Uhlen

Technical University of Denmark (DTU)

Royal Institute of Technology (KTH)

Jens B Nielsen

Technical University of Denmark (DTU)

Royal Institute of Technology (KTH)

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

npj Systems Biology and Applications

2056-7189 (eISSN)

Vol. 3 1 22

Subject Categories

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Bioinformatics and Systems Biology

Genetics

DOI

10.1038/s41540-017-0021-4

More information

Latest update

9/10/2018