Current state of aromatics production using yeast: achievements and challenges
Review article, 2020

Aromatics find a range of applications in the chemical, food, cosmetic and pharmaceutical industries. While production of aromatics on the current market heavily relies on petroleum-derived chemical processes or direct extraction from plants, there is an increasing demand for establishing new renewable and sustainable sources of aromatics. To this end, microbial cell factories-mediated bioproduction using abundant feedstocks comprises a highly promising alternative to aromatics production. In this review, we provide the recent development of de novo biosynthesis of aromatics derived from the shikimate pathway in yeasts, including the model Saccharomyces cerevisiae as well as other non-conventional species. Moreover, we discuss how evolved metabolic engineering tools and strategies contribute to the construction and optimization of aromatics cell factories.

Author

Quanli Liu

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Yi Liu

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Yun Chen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Technical University of Denmark (DTU)

BioInnovation Institute

Current Opinion in Biotechnology

0958-1669 (ISSN)

Vol. 65 65-74

Subject Categories

Production Engineering, Human Work Science and Ergonomics

Other Mechanical Engineering

Chemical Process Engineering

DOI

10.1016/j.copbio.2020.01.008

More information

Latest update

4/14/2020