Current state of aromatics production using yeast: achievements and challenges
Reviewartikel, 2020

Aromatics find a range of applications in the chemical, food, cosmetic and pharmaceutical industries. While production of aromatics on the current market heavily relies on petroleum-derived chemical processes or direct extraction from plants, there is an increasing demand for establishing new renewable and sustainable sources of aromatics. To this end, microbial cell factories-mediated bioproduction using abundant feedstocks comprises a highly promising alternative to aromatics production. In this review, we provide the recent development of de novo biosynthesis of aromatics derived from the shikimate pathway in yeasts, including the model Saccharomyces cerevisiae as well as other non-conventional species. Moreover, we discuss how evolved metabolic engineering tools and strategies contribute to the construction and optimization of aromatics cell factories.

Författare

Quanli Liu

Chalmers, Biologi och bioteknik, Systembiologi

Yi Liu

Chalmers, Biologi och bioteknik, Systembiologi

Yun Chen

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Danmarks Tekniske Universitet (DTU)

BioInnovation Institute

Current Opinion in Biotechnology

0958-1669 (ISSN)

Vol. 65 65-74

Ämneskategorier

Produktionsteknik, arbetsvetenskap och ergonomi

Annan maskinteknik

Kemiska processer

DOI

10.1016/j.copbio.2020.01.008

Mer information

Senast uppdaterat

2020-04-14