Yun Chen

2024

Increased CO<inf>2</inf> fixation enables high carbon-yield production of 3-hydroxypropionic acid in yeast

2024

Relieving metabolic burden to improve robustness and bioproduction by industrial microorganisms

De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast

Phylogenetic analysis and functional characterization of norcoclaurine synthase involved in benzylisoquinoline alkaloids biosynthesis in Stephania tetrandra

Characterization of CYP82 genes involved in the biosynthesis of structurally diverse benzylisoquinoline alkaloids in Corydalis yanhusuo

Identification of the cytochrome P450s responsible for the biosynthesis of two types of aporphine alkaloids and their de novo biosynthesis in yeast

2023

Cinnamic acid and p-coumaric acid are metabolized to 4-hydroxybenzoic acid by Yarrowia lipolytica

2023

Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production

2023

Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast

2023

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast

2023

Restricting Promiscuity of Plant Flavonoid 3'-Hydroxylase and 4'-O-Methyltransferase Improves the Biosynthesis of (2S)-Hesperetin in E. coli

Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph

2023

Optimizing yeast for high-level production of kaempferol and quercetin

2023

Optimization of Pinocembrin Biosynthesis in Saccharomyces cerevisiae

2023

Metabolic engineering: Tools and applications

2023

A highly efficient transcriptome-based biosynthesis of non-ethanol chemicals in Crabtree negative Saccharomyces cerevisiae

2022

Catalytic promiscuity of O-methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids

2022

Metabolic reconfiguration enables synthetic reductive metabolism in yeast

2022

Editorial: Genomic strategies for efficient microbial cell factories

2022

Strategies to increase tolerance and robustness of industrial microorganisms

Metabolic network remodelling enhances yeast’s fitness on xylose using aerobic glycolysis

Functional characterization of (S)–N-methylcoclaurine 3′-hydroxylase (NMCH) involved in the biosynthesis of benzylisoquinoline alkaloids in Corydalis yanhusuo

Metabolic Engineering of Yeast

2021

Yeast optimizes metal utilization based on metabolic network and enzyme kinetics

2021

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

2021

Strategies and challenges with the microbial conversion of methanol to high-value chemicals

Multidimensional engineering of Saccharomyces cerevisiae for efficient synthesis of medium-chain fatty acids

2020

Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution

2020

Current state of aromatics production using yeast: achievements and challenges

Rewiring Central Carbon Metabolism Ensures Increased Provision of Acetyl-CoA and NADPH Required for 3-OH-Propionic Acid Production

Third-generation biorefineries as the means to produce fuels and chemicals from CO2

2019

Metabolic engineering and transcriptomic analysis of Saccharomyces cerevisiae producing p-coumaric acid from xylose

2019

Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae

2019

Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene

Harnessing xylose pathways for biofuels production

Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae

2019

Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

2019

Effects of overexpression of STB5 in Saccharomyces cerevisiae on fatty acid biosynthesis, physiology and transcriptome

Expanding the Dynamic Range of a Transcription Factor-Based Biosensor in Saccharomyces cerevisiae

2018

Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative

Modular Pathway Rewiring of Yeast for Amino Acid Production

2017

Comparison of the metabolic response to over-production of p-coumaric acid in two yeast strains

Elimination of the last reactions in ergosterol biosynthesis alters the resistance of Saccharomyces cerevisiae to multiple stresses

2017

Effects of acetoacetyl-CoA synthase expression on production of farnesene in Saccharomyces cerevisiae

2016

Thermotolerant yeasts selected by adaptive evolution express heat stress response at 30 degrees C

2016

Functional expression and evaluation of heterologous phosphoketolases in Saccharomyces cerevisiae

Biobased organic acids production by metabolically engineered microorganisms

2016

Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway

Ach1 is involved in shuttling mitochondrial acetyl units for cytosolic C2 provision in Saccharomyces cerevisiae lacking pyruvate decarboxylase

2015

Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain

Microbial acetyl-CoA metabolism and metabolic engineering

2015

Production of 3-hydroxypropionic acid from glucose and xylose by metabolically engineered Saccharomyces cerevisiae

2015

De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

Enabling Technologies to Advance Microbial Isoprenoid Production

Functional pyruvate formate lyase pathway expressed with two different electron donors in Saccharomyces cerevisiae at aerobic growth

Altered sterol composition renders yeast thermotolerant

Coupled incremental precursor and co-factor supply improves 3-hydroxypropionic acid production in Saccharomyces cerevisiae

2014

Improving Production of Malonyl Coenzyme A-Derived Metabolites by Abolishing Snf1-Dependent Regulation of Acc1

Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks

Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae

Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism

dynamic control of gene expression in saccharomyces cerevisiae engineered for the production of plant sesquiterpene alpha-santalene in a fed-batch mode

2012

Profiling of Cytosolic and Peroxisomal Acetyl-CoA Metabolism in Saccharomyces cerevisiae

2012

Engineering of acetyl-CoA metabolism for the improved production of polyhydroxybutyrate in Saccharomyces cerevisiae

Enhancing the copy number of episomal plasmids in Saccharomyces cerevisiae for improved protein production

Diversion of Flux toward Sesquiterpene Production in Saccharomyces cerevisiae by Fusion of Host and Heterologous Enzymes