Yun Chen

Forskare at Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Yun Chen is a project leader at Systems and Synthetic Biology group. His research is centered on synthetic biology and metabolic engineering to develop efficient microbial cell factories for sustainable production of both fine chemicals such as isoprenoids that can be used as fragrance, and bulk chemicals such as 3-hydroxypropionic acid that can be used as feedstocks in the chemical industry for polymer production. He is involved in teaching masters course KKR063 Metabolic Engineering.

Source: chalmers.se

Projects

2017–2019

Biosynthesis of the high-value plant secondary metabolites in yeast

Yun Chen Systems and Synthetic Biology
ÅForsk (Ångpanneföreningens Foundation for Research and Development)

2013–2016

Design and Assembly of Novel Pathways for Advanced Biofuel Synthesis

Yun Chen Systems and Synthetic Biology
ÅForsk (Ångpanneföreningens Foundation for Research and Development)

2016–2017

Synthetic biochemical pathways for efficient conversion of xylose into renewable biofuels and chemicals

Yun Chen Systems and Synthetic Biology
Carl Tryggers Stiftelse för Vetenskaplig Forskning

2016–2019

Engineering xylose metabolism for multiple products

Yun Chen Systems and Synthetic Biology
Formas

There might be more projects where Yun Chen participates, but you have to be logged in as a Chalmers employee to see them.

Publications

2017

Effects of acetoacetyl-CoA synthase expression on production of farnesene in Saccharomyces cerevisiae

Yun Chen, Stefan Tippmann, Raphael Ferreira et al
Journal of Industrial Microbiology and Biotechnology. Vol. 44 (6), p. 911-922
Journal article
2016

Thermotolerant yeasts selected by adaptive evolution express heat stress response at 30 degrees C

Jens B Nielsen, Luis Caspeta-Guadarrama, Yun Chen
Scientific Reports. Vol. 6, p. Art. no. 27003-
Journal article
2016

Functional expression and evaluation of heterologous phosphoketolases in Saccharomyces cerevisiae

Alexandra Linda Bergman, Verena Siewers, Jens B Nielsen et al
AMB Express. Vol. 6 (1)
Journal article
2016

Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway

K. Schneider, Il-Kwon Kim, J. Maury et al
Microbial Cell Factories. Vol. 15 (53)
Journal article
2016

Biobased organic acids production by metabolically engineered microorganisms

Yun Chen, Jens B Nielsen
Current Opinion in Biotechnology. Vol. 37, p. 165-172
Journal article
2015

Production of 3-hydroxypropionic acid from glucose and xylose by metabolically engineered Saccharomyces cerevisiae

Zheng Wang, K. R. Kildegaard, Jens B Nielsen et al
Metabolic Engineering Communications. Vol. 2, p. 132-136
Journal article
2015

De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

I. Borodina, A. Rodriguez, Jens B Nielsen et al
Metabolic Engineering. Vol. 32, p. 1-11
Journal article
2015

Functional pyruvate formate lyase pathway expressed with two different electron donors in Saccharomyces cerevisiae at aerobic growth

Anastasia Krivoruchko, Verena Siewers, Zongijie Dai et al
FEMS Yeast Research. Vol. 15 (4)
Journal article
2015

Microbial acetyl-CoA metabolism and metabolic engineering

Jens B Nielsen, Verena Siewers, Anastasia Krivoruchko et al
Metabolic Engineering. Vol. 28, p. 28-42
Journal article
2015

Enabling Technologies to Advance Microbial Isoprenoid Production

Jens B Nielsen, Yongjin Zhou, Verena Siewers et al
Advances in Biochemical Engineering/Biotechnology. Vol. 148, p. 143-160
Journal article
2015

Ach1 is involved in shuttling mitochondrial acetyl units for cytosolic C2 provision in Saccharomyces cerevisiae lacking pyruvate decarboxylase

Jens B Nielsen, Yiming Zhang, Verena Siewers et al
FEMS Yeast Research. Vol. 15 (3), p. 1-8
Journal article
2015

Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain

Verena Siewers, Jens B Nielsen, Yiming Zhang et al
Microbial Cell Factories. Vol. 14 (116)
Journal article
2014

Altered sterol composition renders yeast thermotolerant

Luis Caspeta-Guadarrama, B. M. Hallstrom, Steen Buskov et al
Science. Vol. 346 (6205), p. 75-78
Journal article
2014

Improving Production of Malonyl Coenzyme A-Derived Metabolites by Abolishing Snf1-Dependent Regulation of Acc1

Yun Chen, Jens B Nielsen, S. B. Shi et al
mBio. Vol. 5 (3)
Journal article
2014

Coupled incremental precursor and co-factor supply improves 3-hydroxypropionic acid production in Saccharomyces cerevisiae

Jichen Bao, Verena Siewers, Il-Kwon Kim et al
Metabolic Engineering. Vol. 22, p. 104-109
Journal article
2013

Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism

Yun Chen, M. Schalk, Jens B Nielsen et al
Metabolic Engineering. Vol. 15 (1), p. 48-54
Journal article
2013

Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism

Anastasia Krivoruchko, Verena Siewers, Cristina Serrano-Amatriain et al
Journal of Industrial Microbiology and Biotechnology. Vol. 40 (9), p. 1051-1056
Journal article
2013

Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks

Yun Chen, Jens B Nielsen
Current Opinion in Biotechnology. Vol. 24 (6), p. 956-972
Journal article
2013

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae

Stefan Tippmann, Jens B Nielsen, Verena Siewers et al
Biotechnology journal. Vol. 8 (12), p. 1435-1444
Journal article
2012

Profiling of Cytosolic and Peroxisomal Acetyl-CoA Metabolism in Saccharomyces cerevisiae

Jens B Nielsen, Verena Siewers, Yun Chen
PLoS ONE. Vol. 7 (8), p. e42475-
Journal article
2012

dynamic control of gene expression in saccharomyces cerevisiae engineered for the production of plant sesquiterpene alpha-santalene in a fed-batch mode

Verena Siewers, Yun Chen, Maury Jerome et al
Metabolic Engineering. Vol. 14 (2), p. 91-103
Journal article
2012

Engineering of acetyl-CoA metabolism for the improved production of polyhydroxybutyrate in Saccharomyces cerevisiae

Verena Siewers, Yun Chen, Kanokarn Kocharin et al
AMB Express. Vol. 2 (1)
Journal article
2012

Enhancing the copy number of episomal plasmids in Saccharomyces cerevisiae for improved protein production

Gionata Scalcinati, Verena Siewers, Jens B Nielsen et al
FEMS Yeast Research. Vol. 12 (5), p. 598-607
Journal article
2011

Diversion of Flux toward Sesquiterpene Production in Saccharomyces cerevisiae by Fusion of Host and Heterologous Enzymes

Yun Chen, S. Rattleff, U. H. Mortensen et al
Applied and Environmental Microbiology. Vol. 77 (3), p. 1033-1040
Journal article