Enabling Technologies to Advance Microbial Isoprenoid Production
Artikel i vetenskaplig tidskrift, 2015

Microbial production of isoprenoids provides an attractive alternative to biomass extraction and chemical synthesis. Although widespread research aims for isoprenoid biosynthesis, it is still in its infancy in terms of delivering commercial products. Large barriers remain in realizing a cost-competitive process, for example, developing an optimal microbial cell factory. Here, we summarize the many tools and methods that have been developed in the metabolic engineering of isoprenoid production, with the advent of systems biology and synthetic biology, and discuss how these technologies advance to accelerate the design–build–test engineering cycle to obtain optimum microbial systems. It is anticipated that innovative combinations of new and existing technologies will continue to emerge, which will enable further development of microbial cell factories for commercial isoprenoid production.

Enabling technologies

Metabolic engineering

Sesquiterpenes

Terpenoids

E. coli

S. cerevisiae

Författare

Yun Chen

Chalmers, Biologi och bioteknik, Systembiologi

Yongjin Zhou

Chalmers, Biologi och bioteknik, Systembiologi

Verena Siewers

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Advances in Biochemical Engineering/Biotechnology

0724-6145 (ISSN) 1616-8542 (eISSN)

Vol. 148 143-160

Ämneskategorier

Biologiska vetenskaper

Styrkeområden

Energi

Livsvetenskaper och teknik

DOI

10.1007/10_2014_284

PubMed

25549781